ID   VPB18_MYCTU             Reviewed;          92 AA.
AC   P9WJ47; L0T9Y1; P95008; Q7D6Y2;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Putative antitoxin VapB18;
GN   Name=vapB18; OrderedLocusNames=Rv2545;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Putative antitoxin component of a possible type II toxin-
CC       antitoxin (TA) system. The cognate toxin is VapC18.
CC       {ECO:0000305|PubMed:15718296}.
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DR   EMBL; AL123456; CCP45340.1; -; Genomic_DNA.
DR   PIR; E70659; E70659.
DR   RefSeq; NP_217061.1; NC_000962.3.
DR   RefSeq; WP_003901422.1; NZ_NVQJ01000032.1.
DR   AlphaFoldDB; P9WJ47; -.
DR   SMR; P9WJ47; -.
DR   STRING; 83332.Rv2545; -.
DR   PaxDb; P9WJ47; -.
DR   DNASU; 888038; -.
DR   GeneID; 45426547; -.
DR   GeneID; 888038; -.
DR   KEGG; mtu:Rv2545; -.
DR   TubercuList; Rv2545; -.
DR   eggNOG; COG5450; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   InterPro; IPR019239; VapB_antitoxin.
DR   Pfam; PF09957; VapB_antitoxin; 1.
PE   4: Predicted;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..92
FT                   /note="Putative antitoxin VapB18"
FT                   /id="PRO_0000408064"
SQ   SEQUENCE   92 AA;  10126 MW;  227BB7A3BB7C76DB CRC64;
     MSTTIVAGVI QGHLPVILPT RRRARDLGHT TALFRAQTLQ CIYLSIEYLY VCSMSRRTTI
     DIDDILLARA QAALGTTGLK DRVDAALRAA VR