ID   VPB21_ARCFU             Reviewed;          61 AA.
AC   O28071;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Putative antitoxin VapB21;
GN   Name=vapB21; OrderedLocusNames=AF_2212;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   STRUCTURE BY NMR.
RG   Northeast structural genomics consortium (NESG);
RT   "NMR structure of protein Y2212_ARCFU from Archaeoglobus fulgidus;
RT   Northeast structural genomics consortium target GR83.";
RL   Submitted (FEB-2009) to the PDB data bank.
CC   -!- FUNCTION: Possibly the antitoxin component of a type II toxin-antitoxin
CC       (TA) system. Its cognate toxin is VapC21 (Potential). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0165 family. {ECO:0000305}.
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DR   EMBL; AE000782; AAB89054.1; -; Genomic_DNA.
DR   PIR; D69526; D69526.
DR   RefSeq; WP_010879701.1; NC_000917.1.
DR   PDB; 2NWT; NMR; -; A/B=1-61.
DR   PDBsum; 2NWT; -.
DR   AlphaFoldDB; O28071; -.
DR   BMRB; O28071; -.
DR   SMR; O28071; -.
DR   EnsemblBacteria; AAB89054; AAB89054; AF_2212.
DR   GeneID; 1485442; -.
DR   KEGG; afu:AF_2212; -.
DR   eggNOG; arCOG03880; Archaea.
DR   HOGENOM; CLU_200885_3_1_2; -.
DR   OMA; LHIERHI; -.
DR   OrthoDB; 124687at2157; -.
DR   PhylomeDB; O28071; -.
DR   EvolutionaryTrace; O28071; -.
DR   Proteomes; UP000002199; Chromosome.
DR   Gene3D; 4.10.1150.10; -; 1.
DR   InterPro; IPR008203; AF2212-like.
DR   InterPro; IPR024069; AF2212-like_dom_sf.
DR   Pfam; PF01954; DUF104; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..61
FT                   /note="Putative antitoxin VapB21"
FT                   /id="PRO_0000156857"
FT   STRAND          5..10
FT                   /evidence="ECO:0007829|PDB:2NWT"
FT   STRAND          13..18
FT                   /evidence="ECO:0007829|PDB:2NWT"
FT   STRAND          27..31
FT                   /evidence="ECO:0007829|PDB:2NWT"
FT   HELIX           49..51
FT                   /evidence="ECO:0007829|PDB:2NWT"
SQ   SEQUENCE   61 AA;  6981 MW;  31008F203C0E4CAB CRC64;
     MPKIIEAVYE NGVFKPLQKV DLKEGERVKI KLELKVEPID LGEPVSVEEI KKIRDGTWMS
     S