ID   VPB21_MYCTU             Reviewed;          88 AA.
AC   P9WJ43; L0TDH0; O33300; Q7D6M8;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Antitoxin VapB21;
GN   Name=vapB21; OrderedLocusNames=Rv2758c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   EXPRESSION IN M.SMEGMATIS, AND FUNCTION AS AN ANTITOXIN.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in M.smegmatis neutralizes the effect of cognate toxin
CC       VapC21. {ECO:0000269|PubMed:20011113, ECO:0000305|PubMed:15718296}.
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DR   EMBL; AL123456; CCP45557.1; -; Genomic_DNA.
DR   PIR; E70880; E70880.
DR   RefSeq; NP_217274.1; NC_000962.3.
DR   RefSeq; WP_003414061.1; NZ_NVQJ01000020.1.
DR   AlphaFoldDB; P9WJ43; -.
DR   SMR; P9WJ43; -.
DR   STRING; 83332.Rv2758c; -.
DR   PaxDb; P9WJ43; -.
DR   DNASU; 888263; -.
DR   GeneID; 45426745; -.
DR   GeneID; 888263; -.
DR   KEGG; mtu:Rv2758c; -.
DR   PATRIC; fig|83332.111.peg.3069; -.
DR   TubercuList; Rv2758c; -.
DR   eggNOG; COG5450; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0045927; P:positive regulation of growth; IMP:MTBBASE.
DR   InterPro; IPR019239; VapB_antitoxin.
DR   Pfam; PF09957; VapB_antitoxin; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..88
FT                   /note="Antitoxin VapB21"
FT                   /id="PRO_0000408067"
SQ   SEQUENCE   88 AA;  9494 MW;  C4E4A09307FB118D CRC64;
     MHRGYALVVC SPGVTRTMID IDDDLLARAA KELGTTTKKD TVHAALRAAL RASAARSLMN
     RMAENATGTQ DEALVNAMWR DGHPENTA