ID   VPB26_MYCTU             Reviewed;          71 AA.
AC   O53778; L0T5S8;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Antitoxin VapB26;
GN   Name=vapB26; OrderedLocusNames=Rv0581;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   EXPRESSION IN M.SMEGMATIS, AND FUNCTION AS AN ANTITOXIN.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in M.smegmatis neutralizes the effect of cognate toxin
CC       VapC26. {ECO:0000269|PubMed:20011113}.
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DR   EMBL; AL123456; CCP43319.1; -; Genomic_DNA.
DR   PIR; D70934; D70934.
DR   RefSeq; NP_215095.1; NC_000962.3.
DR   RefSeq; WP_003403039.1; NZ_NVQJ01000033.1.
DR   PDB; 5X3T; X-ray; 2.65 A; A/C/E/G=1-71.
DR   PDBsum; 5X3T; -.
DR   AlphaFoldDB; O53778; -.
DR   SMR; O53778; -.
DR   STRING; 83332.Rv0581; -.
DR   PaxDb; O53778; -.
DR   GeneID; 887739; -.
DR   KEGG; mtu:Rv0581; -.
DR   TubercuList; Rv0581; -.
DR   eggNOG; ENOG5032NDN; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0045927; P:positive regulation of growth; IMP:MTBBASE.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR002145; CopG.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   Pfam; PF01402; RHH_1; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..71
FT                   /note="Antitoxin VapB26"
FT                   /id="PRO_0000408071"
FT   STRAND          2..6
FT                   /evidence="ECO:0007829|PDB:5X3T"
FT   HELIX           10..23
FT                   /evidence="ECO:0007829|PDB:5X3T"
FT   HELIX           27..39
FT                   /evidence="ECO:0007829|PDB:5X3T"
FT   HELIX           61..64
FT                   /evidence="ECO:0007829|PDB:5X3T"
FT   TURN            65..69
FT                   /evidence="ECO:0007829|PDB:5X3T"
SQ   SEQUENCE   71 AA;  7605 MW;  A4B0A063FCD9CC6E CRC64;
     MDKTTVYLPD ELKAAVKRAA RQRGVSEAQV IRESIRAAVG GAKPPPRGGL YAGSEPIARR
     VDELLAGFGE R