VPB28_MYCTU
ID VPB28_MYCTU Reviewed; 81 AA.
AC P9WJ39; L0T763; O07770; Q7D9J7;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=Antitoxin VapB28;
GN Name=vapB28; OrderedLocusNames=Rv0608;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP EXPRESSION IN M.SMEGMATIS, AND FUNCTION AS AN ANTITOXIN.
RC STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA Ramage H.R., Connolly L.E., Cox J.S.;
RT "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT antitoxin systems: implications for pathogenesis, stress responses, and
RT evolution.";
RL PLoS Genet. 5:E1000767-E1000767(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC Upon expression in M.smegmatis neutralizes the effect of cognate toxin
CC VapC28. {ECO:0000269|PubMed:20011113}.
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DR EMBL; AL123456; CCP43347.1; -; Genomic_DNA.
DR PIR; C70910; C70910.
DR RefSeq; NP_215122.1; NC_000962.3.
DR RefSeq; WP_003403184.1; NZ_NVQJ01000033.1.
DR AlphaFoldDB; P9WJ39; -.
DR SMR; P9WJ39; -.
DR STRING; 83332.Rv0608; -.
DR PaxDb; P9WJ39; -.
DR DNASU; 887895; -.
DR GeneID; 45424570; -.
DR GeneID; 887895; -.
DR KEGG; mtu:Rv0608; -.
DR TubercuList; Rv0608; -.
DR eggNOG; COG4423; Bacteria.
DR OMA; LYDDAGM; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0045927; P:positive regulation of growth; IMP:MTBBASE.
DR InterPro; IPR011660; VapB-like.
DR Pfam; PF07704; PSK_trans_fac; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Toxin-antitoxin system.
FT CHAIN 1..81
FT /note="Antitoxin VapB28"
FT /id="PRO_0000408072"
SQ SEQUENCE 81 AA; 8813 MW; 5E1A13D33C10DE65 CRC64;
MALNIKDPSV HQAVKQIAKI TGESQARAVA TAVNERLARL RSDDLAARLL AIGHKTASRM
SPEAKRLDHD ALLYDERGLP A