ID   VPB29_MYCTU             Reviewed;          75 AA.
AC   P9WJ37; F2GMR3; P0CW34; Q8VKH5;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Putative antitoxin VapB29;
GN   Name=vapB29; OrderedLocusNames=Rv0616A;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Possibly the antitoxic component of a type II toxin-antitoxin
CC       (TA) system. Its cognate toxin is VapC29.
CC       {ECO:0000305|PubMed:20011113}.
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DR   EMBL; AL123456; CCP43357.1; -; Genomic_DNA.
DR   RefSeq; WP_003403213.1; NZ_NVQJ01000033.1.
DR   RefSeq; YP_007409270.1; NC_000962.3.
DR   AlphaFoldDB; P9WJ37; -.
DR   SMR; P9WJ37; -.
DR   STRING; 83332.Rv0616A; -.
DR   GeneID; 14515850; -.
DR   GeneID; 45424578; -.
DR   KEGG; mtu:Rv0616A; -.
DR   TubercuList; Rv0616A; -.
DR   eggNOG; ENOG5033ETW; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..75
FT                   /note="Putative antitoxin VapB29"
FT                   /id="PRO_0000408073"
SQ   SEQUENCE   75 AA;  8195 MW;  4AC8F2ADE7D65C9A CRC64;
     MRTTIDLPQD LHKQALAIAR DTHRTLSETV ADLMRRGLAA NRPTALSSDP RTGLPLVSVG
     TVVTSEDVRS LEDEQ