ID   VPB31_MYCTU             Reviewed;          85 AA.
AC   O53811; L0T7D3;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 3.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Antitoxin VapB31;
GN   Name=vapB31; OrderedLocusNames=Rv0748;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   EXPRESSION IN M.SMEGMATIS, AND FUNCTION AS AN ANTITOXIN.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
RN   [3]
RP   INDUCTION IN PERSISTER CELLS.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21673191; DOI=10.1128/mbio.00100-11;
RA   Keren I., Minami S., Rubin E., Lewis K.;
RT   "Characterization and transcriptome analysis of Mycobacterium tuberculosis
RT   persisters.";
RL   MBio 2:E00100-E00111(2011).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in M.smegmatis neutralizes the effect of cognate toxin
CC       VapC31. {ECO:0000269|PubMed:20011113}.
CC   -!- INDUCTION: Induced in persister cells in response to D-cycloserine.
CC       {ECO:0000269|PubMed:21673191}.
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DR   EMBL; AL123456; CCP43493.1; -; Genomic_DNA.
DR   PIR; G70824; G70824.
DR   RefSeq; NP_215262.1; NC_000962.3.
DR   RefSeq; WP_003403834.1; NZ_NVQJ01000035.1.
DR   AlphaFoldDB; O53811; -.
DR   SMR; O53811; -.
DR   STRING; 83332.Rv0748; -.
DR   PaxDb; O53811; -.
DR   GeneID; 45424711; -.
DR   GeneID; 888682; -.
DR   KEGG; mtu:Rv0748; -.
DR   TubercuList; Rv0748; -.
DR   eggNOG; ENOG502ZIAU; Bacteria.
DR   PhylomeDB; O53811; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0045927; P:positive regulation of growth; IMP:MTBBASE.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR002145; CopG.
DR   Pfam; PF01402; RHH_1; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..85
FT                   /note="Antitoxin VapB31"
FT                   /id="PRO_0000408075"
SQ   SEQUENCE   85 AA;  9114 MW;  D785DD670CBF1B64 CRC64;
     MRTTVSISDE ILAAAKRRAR ERGQSLGAVI EDALRREFAA AHVGGARPTV PVFDGGTGPR
     RGIDLTSNRA LSEVLDEGLE LNSRK