ID   VPB33_MYCTU             Reviewed;          86 AA.
AC   O50456; L0T6A4;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 3.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Antitoxin VapB33;
GN   Name=vapB33; OrderedLocusNames=Rv1241;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   EXPRESSION IN M.SMEGMATIS, AND FUNCTION AS AN ANTITOXIN.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in M.smegmatis neutralizes the effect of cognate toxin
CC       VapC33. {ECO:0000269|PubMed:20011113}.
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DR   EMBL; AL123456; CCP43997.1; -; Genomic_DNA.
DR   PIR; H70952; H70952.
DR   RefSeq; NP_215757.1; NC_000962.3.
DR   RefSeq; WP_003406302.1; NZ_NVQJ01000039.1.
DR   AlphaFoldDB; O50456; -.
DR   SMR; O50456; -.
DR   STRING; 83332.Rv1241; -.
DR   PaxDb; O50456; -.
DR   DNASU; 887118; -.
DR   GeneID; 45425211; -.
DR   GeneID; 887118; -.
DR   KEGG; mtu:Rv1241; -.
DR   TubercuList; Rv1241; -.
DR   eggNOG; ENOG5033HGU; Bacteria.
DR   OMA; ADEMEDQ; -.
DR   PhylomeDB; O50456; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0045927; P:positive regulation of growth; IMP:MTBBASE.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..86
FT                   /note="Antitoxin VapB33"
FT                   /id="PRO_0000408077"
SQ   SEQUENCE   86 AA;  9918 MW;  7F72C309438595C2 CRC64;
     MRTTLTLDDD VVRLVEDAVH RERRPMKQVI NDALRRALAP PVKRQEQYRL EPHESAVRSG
     LDLAGFNKLA DELEDEALLD ATRRAR