ID   VPB35_MYCTU             Reviewed;          90 AA.
AC   P9WF17; F2GGQ3; P0CW28; Q8VJT6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Antitoxin VapB35;
GN   Name=vapB35; OrderedLocusNames=Rv1962A;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   EXPRESSION IN M.SMEGMATIS, AND FUNCTION AS AN ANTITOXIN.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in M.smegmatis neutralizes the effect of cognate toxin
CC       VapC35. {ECO:0000269|PubMed:20011113}.
CC   -!- SIMILARITY: Belongs to the phD/YefM antitoxin family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44731.1; -; Genomic_DNA.
DR   RefSeq; WP_003899100.1; NZ_NVQJ01000048.1.
DR   RefSeq; YP_007410641.1; NC_000962.3.
DR   AlphaFoldDB; P9WF17; -.
DR   SMR; P9WF17; -.
DR   STRING; 83332.Rv1962A; -.
DR   GeneID; 14515903; -.
DR   GeneID; 45425933; -.
DR   KEGG; mtu:Rv1962A; -.
DR   TubercuList; Rv1962A; -.
DR   eggNOG; COG4118; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0097351; F:toxin sequestering activity; IBA:GO_Central.
DR   GO; GO:0045927; P:positive regulation of growth; IMP:MTBBASE.
DR   InterPro; IPR036165; YefM-like_sf.
DR   SUPFAM; SSF143120; SSF143120; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..90
FT                   /note="Antitoxin VapB35"
FT                   /id="PRO_0000408048"
FT   REGION          53..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   90 AA;  9818 MW;  F5552E383F018AE7 CRC64;
     MNEVSIRTLN QETSKVLARV KRGEEINLTE RGKVIARIIP ASAGPLDSLI STGSVQPARV
     HGPAPRPTIP MRGGLDSGTL LERMRAEERY