ID   VPB38_MYCTU             Reviewed;          73 AA.
AC   P9WJ25; L0TCP6; O53218; Q7D718;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Putative antitoxin VapB38;
GN   Name=vapB38; OrderedLocusNames=Rv2493;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Probable antitoxin component of a type II toxin-antitoxin
CC       (TA) system. Its putative cognate toxin is VapC38.
CC       {ECO:0000305|PubMed:20011113}.
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DR   EMBL; AL123456; CCP45287.1; -; Genomic_DNA.
DR   PIR; D70869; D70869.
DR   RefSeq; NP_217009.1; NC_000962.3.
DR   RefSeq; WP_003412749.1; NZ_NVQJ01000063.1.
DR   AlphaFoldDB; P9WJ25; -.
DR   SMR; P9WJ25; -.
DR   STRING; 83332.Rv2493; -.
DR   PaxDb; P9WJ25; -.
DR   DNASU; 887480; -.
DR   GeneID; 887480; -.
DR   KEGG; mtu:Rv2493; -.
DR   TubercuList; Rv2493; -.
DR   eggNOG; ENOG5033JQS; Bacteria.
DR   OMA; VREADMR; -.
DR   PhylomeDB; P9WJ25; -.
DR   Proteomes; UP000001584; Chromosome.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..73
FT                   /note="Putative antitoxin VapB38"
FT                   /id="PRO_0000408080"
SQ   SEQUENCE   73 AA;  7897 MW;  F9F37CB2B18A89A2 CRC64;
     MRTTLDLDDD VIAAARELAS SQRRSLGSVI SELARRGLMP GRVEADDGLP VIRVPAGTPP
     ITPEMVRRAL DED