ID   VPB39_MYCTU             Reviewed;          74 AA.
AC   P9WJ23; L0T9W7; Q79FD2; Q8VJG5;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Antitoxin VapB39;
GN   Name=vapB39; OrderedLocusNames=Rv2530A;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   IDENTIFICATION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12368430; DOI=10.1099/00221287-148-10-2967;
RA   Camus J.-C., Pryor M.J., Medigue C., Cole S.T.;
RT   "Re-annotation of the genome sequence of Mycobacterium tuberculosis
RT   H37Rv.";
RL   Microbiology 148:2967-2973(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [3]
RP   EXPRESSION IN M.SMEGMATIS, AND FUNCTION AS AN ANTITOXIN.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in M.smegmatis neutralizes the effect of cognate toxin
CC       VapC39. {ECO:0000269|PubMed:20011113}.
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DR   EMBL; AL123456; CCP45325.1; -; Genomic_DNA.
DR   RefSeq; WP_003412975.1; NZ_NVQJ01000032.1.
DR   RefSeq; YP_177672.1; NC_000962.3.
DR   AlphaFoldDB; P9WJ23; -.
DR   SMR; P9WJ23; -.
DR   STRING; 83332.Rv2530A; -.
DR   PaxDb; P9WJ23; -.
DR   DNASU; 3205085; -.
DR   GeneID; 3205085; -.
DR   GeneID; 45426531; -.
DR   KEGG; mtu:Rv2530A; -.
DR   TubercuList; Rv2530A; -.
DR   eggNOG; ENOG5033NYH; Bacteria.
DR   PhylomeDB; P9WJ23; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0045927; P:positive regulation of growth; IMP:MTBBASE.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..74
FT                   /note="Antitoxin VapB39"
FT                   /id="PRO_0000408081"
SQ   SEQUENCE   74 AA;  7994 MW;  2B1627C3A607F717 CRC64;
     MRTTLQIDDD VLEDARSIAR SEGKSVGAVI SELARRSLRP VGIVEVDGFP VFDVPPDAPT
     VTSEDVVRAL EDDV