ID   VPB40_MYCTO             Reviewed;          81 AA.
AC   P9WFC2; L0TAC2; P65027; Q50626;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Antitoxin VapB40;
GN   Name=vapB40; Synonyms=vapB-mt25; OrderedLocusNames=MT2671.1;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Its cognate toxin is VapC40 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Physically interacts with cognate toxin VapC40. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VapB family. {ECO:0000305}.
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DR   EMBL; AE000516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; B70727; B70727.
DR   RefSeq; WP_003413429.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WFC2; -.
DR   SMR; P9WFC2; -.
DR   GeneID; 45426597; -.
DR   PATRIC; fig|83331.31.peg.2879; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR007159; SpoVT-AbrB_dom.
DR   InterPro; IPR037914; SpoVT-AbrB_sf.
DR   Pfam; PF04014; MazE_antitoxin; 1.
DR   SMART; SM00966; SpoVT_AbrB; 1.
DR   SUPFAM; SSF89447; SSF89447; 1.
DR   TIGRFAMs; TIGR01439; lp_hng_hel_AbrB; 1.
DR   PROSITE; PS51740; SPOVT_ABRB; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Toxin-antitoxin system.
FT   CHAIN           1..81
FT                   /note="Antitoxin VapB40"
FT                   /id="PRO_0000428564"
FT   DOMAIN          1..45
FT                   /note="SpoVT-AbrB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01076"
SQ   SEQUENCE   81 AA;  9250 MW;  0DA5C2D8B50E8D6B CRC64;
     MRTTIDVAGR LVIPKRIRER LGLRGNDQVE ITERDGRIEI EPAPTGVELV REGSVLVARP
     ERPLPPLTDE IVRETLDRTR R