ID   VPB41_MYCTU             Reviewed;          95 AA.
AC   P9WJ21; L0TCV8; Q79FC7; Q8VJF3;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Antitoxin VapB41;
GN   Name=vapB41; OrderedLocusNames=Rv2601A;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   IDENTIFICATION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12368430; DOI=10.1099/00221287-148-10-2967;
RA   Camus J.-C., Pryor M.J., Medigue C., Cole S.T.;
RT   "Re-annotation of the genome sequence of Mycobacterium tuberculosis
RT   H37Rv.";
RL   Microbiology 148:2967-2973(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [3]
RP   EXPRESSION IN M.SMEGMATIS, AND FUNCTION AS AN ANTITOXIN.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in M.smegmatis neutralizes the effect of cognate toxin
CC       VapC41. {ECO:0000269|PubMed:20011113}.
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DR   EMBL; AL123456; CCP45398.1; -; Genomic_DNA.
DR   RefSeq; WP_003413456.1; NZ_NVQJ01000023.1.
DR   RefSeq; YP_177673.1; NC_000962.3.
DR   AlphaFoldDB; P9WJ21; -.
DR   SMR; P9WJ21; -.
DR   STRING; 83332.Rv2601A; -.
DR   PaxDb; P9WJ21; -.
DR   DNASU; 3205108; -.
DR   GeneID; 3205108; -.
DR   KEGG; mtu:Rv2601A; -.
DR   TubercuList; Rv2601A; -.
DR   eggNOG; ENOG502ZXWY; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0045927; P:positive regulation of growth; IMP:MTBBASE.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..95
FT                   /note="Antitoxin VapB41"
FT                   /id="PRO_0000408082"
SQ   SEQUENCE   95 AA;  10454 MW;  0C4C34D0414F9A11 CRC64;
     MKTTLDLPDE LMRAIKVRAA QQGRKMKDVV TELLRSGLSQ THSGAPIPTP RRVQLPLVHC
     GGAATREQEM TPERVAAALL DQEAQWWSGH DDAAL