ID   VPB43_MYCTU             Reviewed;          85 AA.
AC   P9WL41; L0TDL7; P0A5G9; Q10799;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Antitoxin VapB43;
GN   Name=vapB43; OrderedLocusNames=Rv2871; ORFNames=MTCY274.02;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   EXPRESSION IN M.SMEGMATIS, AND FUNCTION AS AN ANTITOXIN.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in M.smegmatis neutralizes the effect of cognate toxin
CC       VapC43. {ECO:0000269|PubMed:20011113}.
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DR   EMBL; AL123456; CCP45673.1; -; Genomic_DNA.
DR   PIR; B70923; B70923.
DR   RefSeq; NP_217387.1; NC_000962.3.
DR   RefSeq; WP_003414620.1; NZ_NVQJ01000006.1.
DR   AlphaFoldDB; P9WL41; -.
DR   SMR; P9WL41; -.
DR   STRING; 83332.Rv2871; -.
DR   PaxDb; P9WL41; -.
DR   DNASU; 887468; -.
DR   GeneID; 45426859; -.
DR   GeneID; 887468; -.
DR   KEGG; mtu:Rv2871; -.
DR   TubercuList; Rv2871; -.
DR   eggNOG; COG3905; Bacteria.
DR   OMA; CMRTTLH; -.
DR   PhylomeDB; P9WL41; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0045927; P:positive regulation of growth; IMP:MTBBASE.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR002145; CopG.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   Pfam; PF01402; RHH_1; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..85
FT                   /note="Antitoxin VapB43"
FT                   /id="PRO_0000104085"
FT   REGION          37..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   85 AA;  9045 MW;  E8AC399ABDE1BBB2 CRC64;
     MRTTIRIDDE LYREVKAKAA RSGRTVAAVL EDAVRRGLNP PKPQAAGRYR VQPSGKGGLR
     PGVDLSSNAA LAEAMNDGVS VDAVR