ID   VPB46_MYCTO             Reviewed;         102 AA.
AC   P9WF12; L0TF80; O50412; Q7D5L3;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Antitoxin VapB46;
GN   Name=vapB46; OrderedLocusNames=MT3493;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Neutralizes the effect of cognate toxin VapC46 (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the phD/YefM antitoxin family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK47829.1; -; Genomic_DNA.
DR   PIR; H70973; H70973.
DR   RefSeq; WP_003417918.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WF12; -.
DR   SMR; P9WF12; -.
DR   EnsemblBacteria; AAK47829; AAK47829; MT3493.
DR   KEGG; mtc:MT3493; -.
DR   PATRIC; fig|83331.31.peg.3749; -.
DR   HOGENOM; CLU_163140_2_2_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   InterPro; IPR006442; Antitoxin_Phd/YefM.
DR   InterPro; IPR036165; YefM-like_sf.
DR   Pfam; PF02604; PhdYeFM_antitox; 1.
DR   SUPFAM; SSF143120; SSF143120; 1.
PE   3: Inferred from homology;
KW   Toxin-antitoxin system.
FT   CHAIN           1..102
FT                   /note="Antitoxin VapB46"
FT                   /id="PRO_0000428619"
SQ   SEQUENCE   102 AA;  11031 MW;  644D4A89C5C2F79D CRC64;
     MTPTACATVS TMTSVGVRAL RQRASELLRR VEAGETIEIT DRGRPVALLS PLPQGGPYEQ
     LLASGEIERA TLDVVDLPEP LDLDAGVELP SVTLARLREH ER