VPB48_MYCTU
ID VPB48_MYCTU Reviewed; 74 AA.
AC P9WJ15; F2GFK6; P0CW36; Q8VIV3;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 30.
DE RecName: Full=Putative antitoxin VapB48;
GN Name=vapB48; OrderedLocusNames=Rv3697A;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION, AND POSSIBLE FUNCTION.
RC STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA Ramage H.R., Connolly L.E., Cox J.S.;
RT "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT antitoxin systems: implications for pathogenesis, stress responses, and
RT evolution.";
RL PLoS Genet. 5:E1000767-E1000767(2009).
CC -!- FUNCTION: Possibly the antitoxin component of a type II toxin-antitoxin
CC (TA) system. Its cognate toxin is VapC48.
CC {ECO:0000305|PubMed:20011113}.
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DR EMBL; AL123456; CCP46522.1; -; Genomic_DNA.
DR RefSeq; WP_003419787.1; NZ_NVQJ01000028.1.
DR RefSeq; YP_007412423.1; NC_000962.3.
DR AlphaFoldDB; P9WJ15; -.
DR SMR; P9WJ15; -.
DR STRING; 83332.Rv3697A; -.
DR GeneID; 14515904; -.
DR KEGG; mtu:Rv3697A; -.
DR TubercuList; Rv3697A; -.
DR eggNOG; ENOG5030PB5; Bacteria.
DR Proteomes; UP000001584; Chromosome.
PE 4: Predicted;
KW Reference proteome; Toxin-antitoxin system.
FT CHAIN 1..74
FT /note="Putative antitoxin VapB48"
FT /id="PRO_0000408085"
SQ SEQUENCE 74 AA; 8465 MW; 7523B43E04943EBD CRC64;
MRTTIDLDDD ILRALKRRQR EERKTLGQLA SELLAQALAA EPPPNVDIRW STADLRPRVD
LDDKDAVWAI LDRG