ID   VPB50_MYCTU             Reviewed;         130 AA.
AC   O69717; F2GHF1; I6XI41; Q7D4X9;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 135.
DE   RecName: Full=Putative antitoxin VapB50 {ECO:0000303|PubMed:24662523};
GN   Name=vapB50 {ECO:0000303|PubMed:24662523};
GN   OrderedLocusNames=Rv3750c, RVBD_3750c; ORFNames=LH57_20430, P425_03902;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RG   The Broad Institute Genome Sequencing Platform;
RA   Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K.,
RA   Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA   Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The genome sequence of Mycobacterium tuberculosis H37Rv.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A.M., Kreiswirth B., Gomez J., Victor T., Desjardins C., Abeel T.,
RA   Young S., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA   Imamovic A., Larimer J., Murphy C., Naylor J., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The genome sequence of Mycobacterium tuberculosis H37Rv.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA   Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA   Monaco A., King S., Sohrabi A.;
RT   "Phylogenetic analysis of Mycobacterial species using whole genome
RT   sequences.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE NAME, DISCUSSION OF FUNCTION, AND REVIEW.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=24662523; DOI=10.3390/toxins6031002;
RA   Sala A., Bordes P., Genevaux P.;
RT   "Multiple toxin-antitoxin systems in Mycobacterium tuberculosis.";
RL   Toxins 6:1002-1020(2014).
CC   -!- FUNCTION: Possibly the antitoxin component of a type II toxin-antitoxin
CC       (TA) system. Its cognate toxin is VapC50.
CC       {ECO:0000305|PubMed:24662523}.
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DR   EMBL; AL123456; CCP46577.1; -; Genomic_DNA.
DR   EMBL; CP003248; AFN51774.1; -; Genomic_DNA.
DR   EMBL; CP009480; AIR16540.1; -; Genomic_DNA.
DR   EMBL; JLDD01000048; KBJ24825.1; -; Genomic_DNA.
DR   RefSeq; NP_218267.1; NC_000962.3.
DR   RefSeq; WP_003420504.1; NC_000962.3.
DR   AlphaFoldDB; O69717; -.
DR   STRING; 83332.Rv3750c; -.
DR   PaxDb; O69717; -.
DR   DNASU; 885807; -.
DR   GeneID; 885807; -.
DR   KEGG; mtu:Rv3750c; -.
DR   KEGG; mtv:RVBD_3750c; -.
DR   PATRIC; fig|83332.111.peg.4171; -.
DR   TubercuList; Rv3750c; -.
DR   eggNOG; COG3311; Bacteria.
DR   HOGENOM; CLU_106726_2_0_11; -.
DR   OMA; RHRRIEF; -.
DR   PhylomeDB; O69717; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR041657; HTH_17.
DR   InterPro; IPR010093; SinI_DNA-bd.
DR   Pfam; PF12728; HTH_17; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR01764; excise; 1.
PE   4: Predicted;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..130
FT                   /note="Putative antitoxin VapB50"
FT                   /id="PRO_0000433059"
SQ   SEQUENCE   130 AA;  14219 MW;  BEF34B74B004B587 CRC64;
     MTSLLEVLGA PEVSVCGNAG QPMTLPEPVR DALYNVVLAL SQGKGISLVP RHLKLTTQEA
     ADLLNISRPT LVRLLEDGRI PFEKPGRHRR VSLDALLEYQ QETRSNRRAA LGELSRDALG
     ELQAALAEKK