VPC16_MYCTU
ID VPC16_MYCTU Reviewed; 141 AA.
AC P0CV93; L0T977;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 44.
DE RecName: Full=Ribonuclease VapC16 {ECO:0000255|HAMAP-Rule:MF_00265};
DE Short=RNase VapC16 {ECO:0000255|HAMAP-Rule:MF_00265};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00265};
DE AltName: Full=Toxin VapC16 {ECO:0000255|HAMAP-Rule:MF_00265};
GN Name=vapC16 {ECO:0000255|HAMAP-Rule:MF_00265}; OrderedLocusNames=Rv2231A;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION, AND POSSIBLE FUNCTION.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=15718296; DOI=10.1093/nar/gki201;
RA Pandey D.P., Gerdes K.;
RT "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT host-associated prokaryotes.";
RL Nucleic Acids Res. 33:966-976(2005).
CC -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. An
CC RNase. The cognate antitoxin is VapB16 (By similarity).
CC {ECO:0000255|HAMAP-Rule:MF_00265}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00265};
CC -!- SIMILARITY: Belongs to the PINc/VapC protein family.
CC {ECO:0000255|HAMAP-Rule:MF_00265}.
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DR EMBL; AL123456; CCP45010.1; -; Genomic_DNA.
DR RefSeq; WP_010886140.1; NZ_NVQJ01000008.1.
DR RefSeq; YP_007410917.1; NC_000962.3.
DR AlphaFoldDB; P0CV93; -.
DR SMR; P0CV93; -.
DR STRING; 83332.Rv2231A; -.
DR GeneID; 14515883; -.
DR KEGG; mtu:Rv2231A; -.
DR TubercuList; Rv2231A; -.
DR eggNOG; COG3744; Bacteria.
DR InParanoid; P0CV93; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR HAMAP; MF_00265; VapC_Nob1; 1.
DR InterPro; IPR022907; VapC_family.
PE 3: Inferred from homology;
KW Hydrolase; Magnesium; Metal-binding; Nuclease; Reference proteome;
KW Toxin-antitoxin system.
FT CHAIN 1..141
FT /note="Ribonuclease VapC16"
FT /id="PRO_0000407875"
FT REGION 99..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 99
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00265"
SQ SEQUENCE 141 AA; 15443 MW; D703322D185FF7E2 CRC64;
MTMACTACPT IWTLRCQTTC SNAFTGEALP HRHPRLAADA VNETRAIVQD VRNSILLSAA
SAWEIAINYR LGKLPPPEPS ASYVPDRMRR CGTSPLSVDH AHTAHRRASG SPSTSIRPCA
HRPGTAAWPD DHHRRRPVSC L
