ID   VPC34_MYCTO             Reviewed;          82 AA.
AC   P9WF70; L0T7S5; O08148; P71999; Q7D817;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Putative ribonuclease VapC34;
DE            Short=Putative RNase VapC34;
DE            EC=3.1.-.-;
DE   AltName: Full=Toxin VapC34;
GN   Name=vapC34; OrderedLocusNames=MT1783;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Toxic component of a possible type II toxin-antitoxin (TA)
CC       system. A putative RNase. Its cognate antitoxin is VapB34 (By
CC       similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the PINc/VapC protein family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46056.1; -; Genomic_DNA.
DR   PIR; F70985; F70985.
DR   RefSeq; WP_003898996.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WF70; -.
DR   SMR; P9WF70; -.
DR   EnsemblBacteria; AAK46056; AAK46056; MT1783.
DR   GeneID; 45425714; -.
DR   KEGG; mtc:MT1783; -.
DR   PATRIC; fig|83331.31.peg.1913; -.
DR   HOGENOM; CLU_194525_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Metal-binding; Nuclease; Toxin-antitoxin system.
FT   CHAIN           1..82
FT                   /note="Putative ribonuclease VapC34"
FT                   /id="PRO_0000428590"
FT   BINDING         4
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   82 AA;  8884 MW;  842630830E12D928 CRC64;
     MVIDTSALVA MLNDEPEAQR FEIAVAADHV WLMSTASYPE MATVIETRFG EPGGREPKVS
     GQPLLYKGDD FACIDIRAVL AG