ID   VPC34_MYCTU             Reviewed;          82 AA.
AC   P9WF71; L0T7S5; O08148; P71999; Q7D817;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Putative ribonuclease VapC34;
DE            Short=Putative RNase VapC34;
DE            EC=3.1.-.-;
DE   AltName: Full=Toxin VapC34;
GN   Name=vapC34; OrderedLocusNames=Rv1741;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
CC   -!- FUNCTION: Toxic component of a possible type II toxin-antitoxin (TA)
CC       system. A putative RNase. Its cognate antitoxin is VapB34 (By
CC       similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the PINc/VapC protein family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44507.1; -; Genomic_DNA.
DR   PIR; F70985; F70985.
DR   RefSeq; NP_216257.1; NC_000962.3.
DR   RefSeq; WP_003898996.1; NZ_NVQJ01000010.1.
DR   AlphaFoldDB; P9WF71; -.
DR   SMR; P9WF71; -.
DR   STRING; 83332.Rv1741; -.
DR   PaxDb; P9WF71; -.
DR   DNASU; 887165; -.
DR   GeneID; 45425714; -.
DR   GeneID; 887165; -.
DR   KEGG; mtu:Rv1741; -.
DR   TubercuList; Rv1741; -.
DR   eggNOG; COG3742; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Metal-binding; Nuclease; Reference proteome;
KW   Toxin-antitoxin system.
FT   CHAIN           1..82
FT                   /note="Putative ribonuclease VapC34"
FT                   /id="PRO_0000413609"
FT   BINDING         4
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   82 AA;  8884 MW;  842630830E12D928 CRC64;
     MVIDTSALVA MLNDEPEAQR FEIAVAADHV WLMSTASYPE MATVIETRFG EPGGREPKVS
     GQPLLYKGDD FACIDIRAVL AG