ID   VPC45_MYCTU             Reviewed;         138 AA.
AC   O53465; F2GG71; I6XD43; Q7D7M3;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Putative ribonuclease VapC45 {ECO:0000303|PubMed:24662523};
DE            Short=RNase VapC45;
DE            EC=3.1.-.-;
DE   AltName: Full=Toxin VapC45 {ECO:0000303|PubMed:24662523};
GN   Name=vapC45 {ECO:0000303|PubMed:24662523};
GN   OrderedLocusNames=Rv2019, RVBD_2019; ORFNames=LH57_11000, P425_02090;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RG   The Broad Institute Genome Sequencing Platform;
RA   Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K.,
RA   Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA   Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The genome sequence of Mycobacterium tuberculosis H37Rv.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A.M., Kreiswirth B., Gomez J., Victor T., Desjardins C., Abeel T.,
RA   Young S., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA   Imamovic A., Larimer J., Murphy C., Naylor J., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Ggnome sequence of Mycobacterium tuberculosis H37Rv.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA   Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA   Monaco A., King S., Sohrabi A.;
RT   "Phylogenetic analysis of Mycobacterial species using whole genome
RT   sequences.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [6]
RP   GENE NAME, DISCUSSION OF FUNCTION, AND REVIEW.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=24662523; DOI=10.3390/toxins6031002;
RA   Sala A., Bordes P., Genevaux P.;
RT   "Multiple toxin-antitoxin systems in Mycobacterium tuberculosis.";
RL   Toxins 6:1002-1020(2014).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. An
CC       RNase. The cognate antitoxin is VapB45. {ECO:0000305|PubMed:24662523}.
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DR   EMBL; AL123456; CCP44791.1; -; Genomic_DNA.
DR   EMBL; CP003248; AFN49959.1; -; Genomic_DNA.
DR   EMBL; CP009480; AIR14769.1; -; Genomic_DNA.
DR   EMBL; JLDD01000023; KBJ33163.1; -; Genomic_DNA.
DR   RefSeq; NP_216535.1; NC_000962.3.
DR   RefSeq; WP_003410114.1; NZ_NVQJ01000046.1.
DR   AlphaFoldDB; O53465; -.
DR   STRING; 83332.Rv2019; -.
DR   PaxDb; O53465; -.
DR   PRIDE; O53465; -.
DR   GeneID; 887665; -.
DR   KEGG; mtu:Rv2019; -.
DR   KEGG; mtv:RVBD_2019; -.
DR   PATRIC; fig|83332.111.peg.2250; -.
DR   TubercuList; Rv2019; -.
DR   eggNOG; ENOG5032SH5; Bacteria.
DR   HOGENOM; CLU_152501_0_0_11; -.
DR   OMA; HGLDRSW; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   InterPro; IPR041375; VapC45_PIN-like.
DR   Pfam; PF18478; PIN_10; 1.
PE   1: Evidence at protein level;
KW   Hydrolase; Nuclease; Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..138
FT                   /note="Putative ribonuclease VapC45"
FT                   /id="PRO_0000433056"
SQ   SEQUENCE   138 AA;  15511 MW;  5CC788F94FE16C55 CRC64;
     MQPDRNLLAD LDHIFVDRSL GAVQVPQLLR DAGFRLTTMR EHYGETQAQS VSDHKWIAMT
     AECGWIGFHK DANIRRNAVE RRTVLDTGAR LFCVPRADIL AEQVAARYIA SLAAIARAAR
     FPGPFIYTVH PSKIVRVL