ID   VPC50_MYCTU             Reviewed;         169 AA.
AC   L0TGF0;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Putative ribonuclease VapC50 {ECO:0000303|PubMed:24662523};
DE            Short=RNase VapC50;
DE            EC=3.1.-.-;
DE   AltName: Full=Toxin VapC50 {ECO:0000303|PubMed:24662523};
GN   Name=vapC50 {ECO:0000303|PubMed:24662523}; OrderedLocusNames=Rv3749c;
GN   ORFNames=LH57_20425;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA   Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA   Monaco A., King S., Sohrabi A.;
RT   "Phylogenetic analysis of Mycobacterial species using whole genome
RT   sequences.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [4]
RP   GENE NAME, DISCUSSION OF FUNCTION, AND REVIEW.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=24662523; DOI=10.3390/toxins6031002;
RA   Sala A., Bordes P., Genevaux P.;
RT   "Multiple toxin-antitoxin systems in Mycobacterium tuberculosis.";
RL   Toxins 6:1002-1020(2014).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. An
CC       RNase. The cognate antitoxin is VapB50. {ECO:0000305|PubMed:24662523}.
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DR   EMBL; AL123456; CCP46576.1; -; Genomic_DNA.
DR   EMBL; CP009480; AIR16539.1; -; Genomic_DNA.
DR   RefSeq; NP_218266.1; NC_000962.3.
DR   RefSeq; WP_003899673.1; NC_018143.2.
DR   AlphaFoldDB; L0TGF0; -.
DR   STRING; 83332.Rv3749c; -.
DR   PaxDb; L0TGF0; -.
DR   DNASU; 885384; -.
DR   GeneID; 885384; -.
DR   KEGG; mtu:Rv3749c; -.
DR   PATRIC; fig|83332.12.peg.4178; -.
DR   TubercuList; Rv3749c; -.
DR   eggNOG; COG1569; Bacteria.
DR   HOGENOM; CLU_1576796_0_0_11; -.
DR   OMA; AMNNHDK; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Hydrolase; Nuclease; Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..169
FT                   /note="Putative ribonuclease VapC50"
FT                   /id="PRO_0000433057"
SQ   SEQUENCE   169 AA;  18523 MW;  8391A270AEF709DB CRC64;
     MPCCGSLTRA PIGLCGRRTS WPRLGEPWST ASTSAPNGLT TAFAFGYNDL IAAMNNHYKD
     RHVLAAAVRE RAEVIVTTNL KHFPDDALKP YQIKALHPDD FLLDQLDLYE EATKAVILGM
     VDAYIDPPFT PHSLLDALGE QVPQFAAKAR RLFPSGSPFG LGVLLPFDQ