ID   VPI_CHATC               Reviewed;          66 AA.
AC   P0DM57;
DT   24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2013, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Venom peptide CtAPI {ECO:0000303|PubMed:23533574};
DE   AltName: Full=Ascaris-type protease inhibitor {ECO:0000305};
OS   Chaerilus tricostatus (Scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Chaerilida; Chaeriloidea; Chaerilidae; Chaerilus.
OX   NCBI_TaxID=1055734;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=23533574; DOI=10.1371/journal.pone.0057529;
RA   Chen Z., Wang B., Hu J., Yang W., Cao Z., Zhuo R., Li W., Wu Y.;
RT   "SjAPI, the first functionally characterized Ascaris-type protease
RT   inhibitor from animal venoms.";
RL   PLoS ONE 8:E57529-E57529(2013).
CC   -!- FUNCTION: Serine protease inhibitor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:23533574}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:23533574}.
CC   -!- SIMILARITY: Belongs to the serine protease inhibitor-like (TIL domain-
CC       containing) family. {ECO:0000305}.
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DR   AlphaFoldDB; P0DM57; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   Pfam; PF01826; TIL; 1.
DR   SUPFAM; SSF57567; SSF57567; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Protease inhibitor; Secreted; Serine protease inhibitor.
FT   CHAIN           1..66
FT                   /note="Venom peptide CtAPI"
FT                   /id="PRO_0000423044"
FT   DOMAIN          7..64
FT                   /note="TIL"
FT   DISULFID        7..44
FT                   /evidence="ECO:0000250"
FT   DISULFID        16..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        20..33
FT                   /evidence="ECO:0000250"
FT   DISULFID        24..64
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..58
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   66 AA;  7466 MW;  59124B2138307C94 CRC64;
     QPNLWRCEKD EEFVNCAPRC PQNCRNIRSY QPCLVLTPVC APGCVCRSGK VKNDRGDCVS
     ITDCFK