CALM_TRYCR
ID CALM_TRYCR Reviewed; 149 AA.
AC P18061;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Calmodulin;
DE Short=CaM;
GN Name=CALA2;
OS Trypanosoma cruzi.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=5693;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CL;
RX PubMed=2167471; DOI=10.1093/nar/18.15.4561;
RA Chung S.H., Swindle J.;
RT "Linkage of the calmodulin and ubiquitin loci in Trypanosoma cruzi.";
RL Nucleic Acids Res. 18:4561-4569(1990).
CC -!- FUNCTION: Calmodulin mediates the control of a large number of enzymes,
CC ion channels and other proteins by Ca(2+). Among the enzymes to be
CC stimulated by the calmodulin-Ca(2+) complex are a number of protein
CC kinases and phosphatases.
CC -!- MISCELLANEOUS: This protein has four functional calcium-binding sites.
CC -!- SIMILARITY: Belongs to the calmodulin family. {ECO:0000305}.
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DR EMBL; X52096; CAA36316.1; -; Genomic_DNA.
DR PIR; S10995; MCUTC.
DR AlphaFoldDB; P18061; -.
DR SMR; P18061; -.
DR PRIDE; P18061; -.
DR VEuPathDB; TriTrypDB:BCY84_04470; -.
DR VEuPathDB; TriTrypDB:BCY84_17806; -.
DR VEuPathDB; TriTrypDB:BCY84_17807; -.
DR VEuPathDB; TriTrypDB:BCY84_17808; -.
DR VEuPathDB; TriTrypDB:C3747_16g1127c; -.
DR VEuPathDB; TriTrypDB:C3747_16g1130c; -.
DR VEuPathDB; TriTrypDB:C3747_16g219; -.
DR VEuPathDB; TriTrypDB:C3747_46g16; -.
DR VEuPathDB; TriTrypDB:C3747_46g81c; -.
DR VEuPathDB; TriTrypDB:C4B63_138g113c; -.
DR VEuPathDB; TriTrypDB:C4B63_138g116c; -.
DR VEuPathDB; TriTrypDB:C4B63_138g27; -.
DR VEuPathDB; TriTrypDB:C4B63_275g1; -.
DR VEuPathDB; TriTrypDB:C4B63_275g4c; -.
DR VEuPathDB; TriTrypDB:C4B63_292g76c; -.
DR VEuPathDB; TriTrypDB:C4B63_292g78c; -.
DR VEuPathDB; TriTrypDB:TcBrA4_0110110; -.
DR VEuPathDB; TriTrypDB:TcBrA4_0110120; -.
DR VEuPathDB; TriTrypDB:TcBrA4_0110130; -.
DR VEuPathDB; TriTrypDB:TcCL_ESM07169; -.
DR VEuPathDB; TriTrypDB:TcCL_NonESM13681; -.
DR VEuPathDB; TriTrypDB:TcCLB.506391.10; -.
DR VEuPathDB; TriTrypDB:TcCLB.506391.20; -.
DR VEuPathDB; TriTrypDB:TcCLB.507483.39; -.
DR VEuPathDB; TriTrypDB:TCDM_10682; -.
DR VEuPathDB; TriTrypDB:TcG_09238; -.
DR VEuPathDB; TriTrypDB:TcYC6_0037200; -.
DR VEuPathDB; TriTrypDB:TcYC6_0037210; -.
DR VEuPathDB; TriTrypDB:TcYC6_0037220; -.
DR OMA; HQIEFDE; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019722; P:calcium-mediated signaling; IEA:InterPro.
DR CDD; cd00051; EFh; 2.
DR InterPro; IPR039030; Calmodulin.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR23050:SF401; PTHR23050:SF401; 1.
DR Pfam; PF13499; EF-hand_7; 2.
DR SMART; SM00054; EFh; 4.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 4.
DR PROSITE; PS50222; EF_HAND_2; 4.
PE 3: Inferred from homology;
KW Calcium; Metal-binding; Methylation; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..149
FT /note="Calmodulin"
FT /id="PRO_0000198277"
FT DOMAIN 8..43
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 44..79
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 81..116
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 117..149
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 21
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 23
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 25
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 27
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 32
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 57
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 59
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 61
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 63
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 68
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 94
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 96
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 98
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 105
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 130
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 132
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 134
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 136
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 141
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT MOD_RES 116
FT /note="N6,N6,N6-trimethyllysine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 149 AA; 16825 MW; 5D55062862170230 CRC64;
MADQLSNEQI SEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDQDG
SGTIDFPEFL TLMARKMQDS DSEEEIKEAF RVFDKDGNGF ISAAELRHVM TNLGEKLTDE
EVDEMIREAD VDGDGQINYE EFVKMMMSK
