VPRE2_MOUSE
ID VPRE2_MOUSE Reviewed; 142 AA.
AC P13373;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Immunoglobulin omega chain;
DE AltName: Full=Protein VPreB2;
DE Flags: Precursor;
GN Name=Vpreb2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6 X DBA/2J;
RX PubMed=3117530; DOI=10.1002/j.1460-2075.1987.tb02500.x;
RA Kudo A., Melchers F.;
RT "A second gene, VpreB in the lambda 5 locus of the mouse, which appears to
RT be selectively expressed in pre-B lymphocytes.";
RL EMBO J. 6:2267-2272(1987).
CC -!- FUNCTION: Associates with the Ig-mu chain to form a molecular complex
CC that is expressed on the surface of pre-B-cells. This complex
CC presumably regulates Ig gene rearrangements in the early steps of B-
CC cell differentiation.
CC -!- TISSUE SPECIFICITY: Only expressed by pre-B-cells.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
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DR EMBL; X05563; CAA29077.1; -; Genomic_DNA.
DR CCDS; CCDS28015.1; -.
DR PIR; B28344; B28344.
DR RefSeq; NP_058679.1; NM_016983.1.
DR AlphaFoldDB; P13373; -.
DR SMR; P13373; -.
DR STRING; 10090.ENSMUSP00000074835; -.
DR PaxDb; P13373; -.
DR PRIDE; P13373; -.
DR DNASU; 22363; -.
DR Ensembl; ENSMUST00000075371; ENSMUSP00000074835; ENSMUSG00000059280.
DR GeneID; 22363; -.
DR KEGG; mmu:22363; -.
DR UCSC; uc007ymq.1; mouse.
DR CTD; 22363; -.
DR MGI; MGI:98937; Vpreb2.
DR VEuPathDB; HostDB:ENSMUSG00000059280; -.
DR eggNOG; ENOG502RTXJ; Eukaryota.
DR GeneTree; ENSGT00940000161017; -.
DR HOGENOM; CLU_077975_4_0_1; -.
DR InParanoid; P13373; -.
DR OMA; VYSIYWY; -.
DR OrthoDB; 1507021at2759; -.
DR PhylomeDB; P13373; -.
DR TreeFam; TF352061; -.
DR Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
DR BioGRID-ORCS; 22363; 4 hits in 47 CRISPR screens.
DR PRO; PR:P13373; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; P13373; protein.
DR Bgee; ENSMUSG00000059280; Expressed in bone marrow and 9 other tissues.
DR Genevisible; P13373; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0001782; P:B cell homeostasis; IGI:MGI.
DR GO; GO:0042100; P:B cell proliferation; IGI:MGI.
DR GO; GO:0000902; P:cell morphogenesis; IGI:MGI.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0008361; P:regulation of cell size; IGI:MGI.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Immunoglobulin domain; Reference proteome; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..142
FT /note="Immunoglobulin omega chain"
FT /id="PRO_0000015002"
FT REGION 20..41
FT /note="Framework-1"
FT REGION 42..56
FT /note="Complementarity-determining-1"
FT REGION 57..70
FT /note="Framework-2"
FT REGION 71..81
FT /note="Complementarity-determining-2"
FT REGION 82..115
FT /note="Framework-3"
FT DISULFID 41..115
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 142 AA; 16052 MW; 7EA7128A4E63D920 CRC64;
MAWTSVLLML LAHLTGCGPQ PMVHQPPSAS SSLGATIRLS CTLSNDHNIG IYSIYWYQQR
PGHPPRFLLR YFSHSDKHQG PDIPPRFSGS KDTARNLGYL SISELQPEDE AVYYCAVGLR
SHEKKRMERE WEGEKSYTDL GS
