ID   VPRE3_HUMAN             Reviewed;         123 AA.
AC   Q9UKI3; B2R587;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 159.
DE   RecName: Full=Pre-B lymphocyte protein 3;
DE   AltName: Full=N27C7-2;
DE   AltName: Full=Protein VPreB3;
DE   Flags: Precursor;
GN   Name=VPREB3; ORFNames=UNQ355/PRO619;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10702669; DOI=10.1159/000015468;
RA   Rosnet O., Mattei M.-G., Delattre O., Schiff C.;
RT   "VPREB3: cDNA characterization and expression in human and chromosome
RT   mapping in human and mouse.";
RL   Cytogenet. Cell Genet. 87:205-208(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Shimizu N., Minosima S., Kawasaki K., Sasaki T., Hosono K.;
RT   "Molecular cloning of N27C7-2 gene.";
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA   Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA   Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA   Beare D.M., Dunham I.;
RT   "A genome annotation-driven approach to cloning the human ORFeome.";
RL   Genome Biol. 5:R84.1-R84.11(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Associates with the Ig-mu chain to form a molecular complex
CC       that is expressed on the surface of pre-B-cells.
CC   -!- TISSUE SPECIFICITY: Expressed in B-cell precursors. Expressed in fetal
CC       liver, bone marrow, spleen and lymph node.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
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DR   EMBL; AF163825; AAF09451.1; -; mRNA.
DR   EMBL; AB050772; BAB83034.1; -; Genomic_DNA.
DR   EMBL; AY359000; AAQ89359.1; -; mRNA.
DR   EMBL; CR456610; CAG30496.1; -; mRNA.
DR   EMBL; AK312098; BAG35034.1; -; mRNA.
DR   EMBL; CH471095; EAW59598.1; -; Genomic_DNA.
DR   EMBL; BC020666; AAH20666.1; -; mRNA.
DR   CCDS; CCDS13813.1; -.
DR   RefSeq; NP_037510.1; NM_013378.2.
DR   AlphaFoldDB; Q9UKI3; -.
DR   SMR; Q9UKI3; -.
DR   STRING; 9606.ENSP00000248948; -.
DR   BioMuta; VPREB3; -.
DR   DMDM; 11387357; -.
DR   MassIVE; Q9UKI3; -.
DR   PaxDb; Q9UKI3; -.
DR   PeptideAtlas; Q9UKI3; -.
DR   PRIDE; Q9UKI3; -.
DR   ProteomicsDB; 84790; -.
DR   Antibodypedia; 298; 113 antibodies from 24 providers.
DR   DNASU; 29802; -.
DR   Ensembl; ENST00000248948.4; ENSP00000248948.3; ENSG00000128218.8.
DR   GeneID; 29802; -.
DR   KEGG; hsa:29802; -.
DR   MANE-Select; ENST00000248948.4; ENSP00000248948.3; NM_013378.3; NP_037510.1.
DR   UCSC; uc002zxt.4; human.
DR   CTD; 29802; -.
DR   DisGeNET; 29802; -.
DR   GeneCards; VPREB3; -.
DR   HGNC; HGNC:12710; VPREB3.
DR   HPA; ENSG00000128218; Tissue enhanced (epididymis, intestine, lymphoid tissue).
DR   MIM; 605017; gene.
DR   neXtProt; NX_Q9UKI3; -.
DR   OpenTargets; ENSG00000128218; -.
DR   PharmGKB; PA37325; -.
DR   VEuPathDB; HostDB:ENSG00000128218; -.
DR   eggNOG; ENOG502SQUV; Eukaryota.
DR   GeneTree; ENSGT00940000161808; -.
DR   InParanoid; Q9UKI3; -.
DR   OMA; DVAHNAC; -.
DR   OrthoDB; 1507021at2759; -.
DR   PhylomeDB; Q9UKI3; -.
DR   TreeFam; TF352061; -.
DR   PathwayCommons; Q9UKI3; -.
DR   Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR   BioGRID-ORCS; 29802; 6 hits in 1064 CRISPR screens.
DR   ChiTaRS; VPREB3; human.
DR   GeneWiki; VPREB3; -.
DR   GenomeRNAi; 29802; -.
DR   Pharos; Q9UKI3; Tbio.
DR   PRO; PR:Q9UKI3; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; Q9UKI3; protein.
DR   Bgee; ENSG00000128218; Expressed in lymph node and 110 other tissues.
DR   ExpressionAtlas; Q9UKI3; baseline and differential.
DR   Genevisible; Q9UKI3; HS.
DR   GO; GO:0005783; C:endoplasmic reticulum; NAS:ProtInc.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Immunoglobulin domain; Reference proteome; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..123
FT                   /note="Pre-B lymphocyte protein 3"
FT                   /id="PRO_0000015003"
FT   DOMAIN          21..123
FT                   /note="Ig-like"
FT   DISULFID        40..115
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   VARIANT         4
FT                   /note="R -> W (in dbSNP:rs34372784)"
FT                   /id="VAR_049954"
SQ   SEQUENCE   123 AA;  13710 MW;  BF09AC5196059E85 CRC64;
     MACRCLSFLL MGTFLSVSQT VLAQLDALLV FPGQVAQLSC TLSPQHVTIR DYGVSWYQQR
     AGSAPRYLLY YRSEEDHHRP ADIPDRFSAA KDEAHNACVL TISPVQPEDD ADYYCSVGYG
     FSP