VPREB_MOUSE
ID VPREB_MOUSE Reviewed; 142 AA.
AC P13372;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Immunoglobulin iota chain;
DE AltName: Full=Protein VPreB1;
DE AltName: CD_antigen=CD179a;
DE Flags: Precursor;
GN Name=Vpreb1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=C57BL/6 X DBA/2J;
RX PubMed=3117530; DOI=10.1002/j.1460-2075.1987.tb02500.x;
RA Kudo A., Melchers F.;
RT "A second gene, VpreB in the lambda 5 locus of the mouse, which appears to
RT be selectively expressed in pre-B lymphocytes.";
RL EMBO J. 6:2267-2272(1987).
RN [2]
RP INTERACTION WITH SYVN1, AND SUBCELLULAR LOCATION.
RX PubMed=29907570; DOI=10.1074/jbc.ra117.001267;
RA Yang Y., Kong S., Zhang Y., Melo-Cardenas J., Gao B., Zhang Y., Zhang D.D.,
RA Zhang B., Song J., Thorp E., Zhang K., Zhang J., Fang D.;
RT "The endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls a
RT critical checkpoint in B cell development in mice.";
RL J. Biol. Chem. 293:12934-12944(2018).
CC -!- FUNCTION: Associates with the Ig-mu chain to form a molecular complex
CC that is expressed on the surface of pre-B-cells. This complex
CC presumably regulates Ig gene rearrangements in the early steps of B-
CC cell differentiation.
CC -!- SUBUNIT: Interacts with IGLL1 (By similarity). Interacts with
CC SYNV1/HRD1 (via N-terminus); this interaction leads to increased VPREB1
CC ubiquitination and degradation in pre-B cells, possibly through a
CC lysosomal, not proteasomal, pathway (PubMed:29907570).
CC {ECO:0000250|UniProtKB:P12018, ECO:0000269|PubMed:29907570}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000305|PubMed:29907570}.
CC -!- TISSUE SPECIFICITY: Only expressed by pre-B-cells.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
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DR EMBL; X05556; CAA29071.1; -; mRNA.
DR EMBL; X05557; CAA29072.1; -; Genomic_DNA.
DR CCDS; CCDS27989.1; -.
DR PIR; A28344; A28344.
DR RefSeq; NP_058678.1; NM_016982.2.
DR AlphaFoldDB; P13372; -.
DR SMR; P13372; -.
DR BioGRID; 204532; 1.
DR STRING; 10090.ENSMUSP00000074537; -.
DR PhosphoSitePlus; P13372; -.
DR PaxDb; P13372; -.
DR PRIDE; P13372; -.
DR DNASU; 22362; -.
DR Ensembl; ENSMUST00000075017; ENSMUSP00000074537; ENSMUSG00000059305.
DR GeneID; 22362; -.
DR KEGG; mmu:22362; -.
DR UCSC; uc007yjg.2; mouse.
DR CTD; 7441; -.
DR MGI; MGI:98936; Vpreb1.
DR VEuPathDB; HostDB:ENSMUSG00000059305; -.
DR eggNOG; ENOG502RTXJ; Eukaryota.
DR GeneTree; ENSGT00940000161017; -.
DR HOGENOM; CLU_077975_4_0_1; -.
DR InParanoid; P13372; -.
DR OMA; DINMYNI; -.
DR OrthoDB; 1507021at2759; -.
DR PhylomeDB; P13372; -.
DR TreeFam; TF352061; -.
DR BioGRID-ORCS; 22362; 0 hits in 39 CRISPR screens.
DR PRO; PR:P13372; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; P13372; protein.
DR Bgee; ENSMUSG00000059305; Expressed in choroid plexus and 60 other tissues.
DR ExpressionAtlas; P13372; baseline and differential.
DR Genevisible; P13372; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IPI:MGI.
DR GO; GO:0038023; F:signaling receptor activity; IPI:MGI.
DR GO; GO:0001782; P:B cell homeostasis; IGI:MGI.
DR GO; GO:0042100; P:B cell proliferation; IMP:MGI.
DR GO; GO:0000902; P:cell morphogenesis; IGI:MGI.
DR GO; GO:0030097; P:hemopoiesis; IMP:MGI.
DR GO; GO:0006955; P:immune response; IPI:MGI.
DR GO; GO:0008361; P:regulation of cell size; IDA:MGI.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Endoplasmic reticulum; Immunoglobulin domain;
KW Reference proteome; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..142
FT /note="Immunoglobulin iota chain"
FT /id="PRO_0000015001"
FT REGION 20..41
FT /note="Framework-1"
FT REGION 42..56
FT /note="Complementarity-determining-1"
FT REGION 57..70
FT /note="Framework-2"
FT REGION 71..81
FT /note="Complementarity-determining-2"
FT REGION 82..115
FT /note="Framework-3"
FT DISULFID 41..115
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 142 AA; 16125 MW; 2E18BF963A0F448C CRC64;
MAWTSVLLML LAYLTGCGPQ PMVHQPPLAS SSLGATIRLS CTLSNDHNIG IYSIYWYQQR
PGHPPRFLLR YFSHSDKHQG PDIPPRFSGS KDTTRNLGYL SISELQPEDE AVYYCAVGLR
SQEKKRMERE WEGEKSYTDL GS