ID   VPRL_CAEVC              Reviewed;          87 AA.
AC   P21124;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Probable Vpr-like protein;
DE   AltName: Full=Protein S;
DE   AltName: Full=Protein Tat;
GN   Name=tat;
OS   Caprine arthritis encephalitis virus (strain Cork) (CAEV-Co).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11661;
OH   NCBI_TaxID=9925; Capra hircus (Goat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1845832; DOI=10.1016/0042-6822(91)90044-c;
RA   Jackson M.K., Knowles D.P., Stem T.A., Harwood W.G., Robinson M.M.,
RA   Cheevers W.P.;
RT   "Genetic structure of the pol-env region of the caprine arthritis-
RT   encephalitis lentivirus genome.";
RL   Virology 180:389-394(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2171210; DOI=10.1016/0042-6822(90)90303-9;
RA   Saltarelli M., Querat G., Konings D.A.M., Vigne R., Clements J.E.;
RT   "Nucleotide sequence and transcriptional analysis of molecular clones of
RT   CAEV which generate infectious virus.";
RL   Virology 179:347-364(1990).
RN   [3]
RP   FUNCTION.
RX   PubMed=12667801; DOI=10.1016/s0042-6822(02)00076-4;
RA   Villet S., Faure C., Bouzar B.A., Morin T., Verdier G., Chebloune Y.,
RA   Legras C.;
RT   "Lack of trans-activation function for Maedi Visna virus and Caprine
RT   arthritis encephalitis virus Tat proteins.";
RL   Virology 307:317-327(2003).
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=12915575; DOI=10.1128/jvi.77.17.9632-9638.2003;
RA   Villet S., Bouzar B.A., Morin T., Verdier G., Legras C., Chebloune Y.;
RT   "Maedi-visna virus and caprine arthritis encephalitis virus genomes encode
RT   a Vpr-like but no Tat protein.";
RL   J. Virol. 77:9632-9638(2003).
CC   -!- FUNCTION: Seems to function as a Vpr-like protein, since it mediates
CC       host cell cycle arrest in G2 phase. Cell cycle arrest creates a
CC       favorable environment for maximizing viral expression and production.
CC       {ECO:0000269|PubMed:12667801, ECO:0000269|PubMed:12915575}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host nucleus
CC       {ECO:0000269|PubMed:12915575}.
CC   -!- CAUTION: Was first thought to be the equivalent of lentiviral Tat
CC       protein, but it does not induce any transactivation of viral LTR
CC       promoter, or if any, at very low rate. The LTR promoter of this virus
CC       has a high basal activity and does apparently not need transactivation
CC       by a Tat-like protein. {ECO:0000305}.
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DR   EMBL; M34092; AAA42890.1; -; Genomic_RNA.
DR   EMBL; M33677; AAA91828.1; -; Genomic_RNA.
DR   PIR; D45345; D45345.
DR   RefSeq; NP_040941.1; NC_001463.1.
DR   SMR; P21124; -.
DR   GeneID; 1724701; -.
DR   KEGG; vg:1724701; -.
DR   Proteomes; UP000203242; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR004247; Lentiviral_Vpr-like.
DR   Pfam; PF02998; Lentiviral_Tat; 1.
PE   4: Predicted;
KW   Cell cycle; Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..87
FT                   /note="Probable Vpr-like protein"
FT                   /id="PRO_0000085485"
FT   MOTIF           40..47
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           48..55
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        37
FT                   /note="E -> A (in Ref. 2; AAA91828)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        70
FT                   /note="G -> A (in Ref. 2; AAA91828)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   87 AA;  10670 MW;  8A596E19E23A5B45 CRC64;
     MSEELPQRRE THPEELVRNV RERERDTWQW TSIRVPEEIL QRWLAMLRSG RNRKKVYREM
     QKWMWIHPKG PVIRACGCRL CNPGWGT