ID   VPRL_CAEVG              Reviewed;          87 AA.
AC   P21125;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   29-SEP-2021, entry version 63.
DE   RecName: Full=Probable Vpr-like protein;
DE   AltName: Full=Protein S;
DE   AltName: Full=Protein Tat;
GN   Name=tat;
OS   Caprine arthritis encephalitis virus (strain 63) (CAEV-63).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11662;
OH   NCBI_TaxID=9925; Capra hircus (Goat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1845832; DOI=10.1016/0042-6822(91)90044-c;
RA   Jackson M.K., Knowles D.P., Stem T.A., Harwood W.G., Robinson M.M.,
RA   Cheevers W.P.;
RT   "Genetic structure of the pol-env region of the caprine arthritis-
RT   encephalitis lentivirus genome.";
RL   Virology 180:389-394(1991).
CC   -!- FUNCTION: Seems to function as a Vpr-like protein, since it mediates
CC       host cell cycle arrest in G2 phase. Cell cycle arrest creates a
CC       favorable environment for maximizing viral expression and production
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host nucleus {ECO:0000250}.
CC   -!- CAUTION: Was first thought to be the equivalent of lentiviral Tat
CC       protein, but it does not induce any transactivation of viral LTR
CC       promoter, or if any, at very low rate. The LTR promoter of this virus
CC       has a high basal activity and does apparently not need transactivation
CC       by a Tat-like protein. {ECO:0000305}.
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DR   EMBL; M34093; AAA42891.1; -; Genomic_RNA.
DR   SMR; P21125; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR004247; Lentiviral_Vpr-like.
DR   Pfam; PF02998; Lentiviral_Tat; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Host nucleus; Virion.
FT   CHAIN           1..87
FT                   /note="Probable Vpr-like protein"
FT                   /id="PRO_0000085486"
FT   MOTIF           40..47
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           48..55
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   87 AA;  10781 MW;  818E2CCB3ED7FB64 CRC64;
     MSERLPQRRE VHPEERVRNI WERERDTWQW TSIRVPEEIL QRWLAMLRSG RNRNKVYREM
     QKWMSIHPKA PVIRPCGCRL CNPGWET