ID   VPRL_FIVPE              Reviewed;          78 AA.
AC   Q66013;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-SEP-2021, entry version 46.
DE   RecName: Full=Probable Vpr-like protein;
DE   AltName: Full=ORF2;
DE   AltName: Full=OrfA;
DE   AltName: Full=Protein Tat;
OS   Feline immunodeficiency virus (isolate Petaluma) (FIV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11674;
OH   NCBI_TaxID=9681; Felidae (cat family).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Clone 34TF10;
RX   PubMed=2762293; DOI=10.1073/pnas.86.15.5743;
RA   Talbott R.L., Sparger E.E., Lovelace K.M., Fitch W.M., Pedersen N.C.,
RA   Luciw P.A., Elder J.H.;
RT   "Nucleotide sequence and genomic organization of feline immunodeficiency
RT   virus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:5743-5747(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Clone FIV-14;
RX   PubMed=2813380; DOI=10.1073/pnas.86.20.8088;
RA   Olmsted R.A., Hirsch V.M., Purcell R.H., Johnson P.R.;
RT   "Nucleotide sequence analysis of feline immunodeficiency virus: genome
RT   organization and relationship to other lentiviruses.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:8088-8092(1989).
CC   -!- FUNCTION: Seems to function as a Vpr-like protein, since it mediates
CC       host cell cycle arrest in G2 phase. Cell cycle arrest creates a
CC       favorable environment for maximizing viral expression and production
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host nucleus. Note=Contains
CC       both nuclear import and nuclear export signals. {ECO:0000250}.
CC   -!- CAUTION: Was first thought to be the equivalent of lentiviral Tat
CC       protein. {ECO:0000305}.
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DR   EMBL; M25381; AAB59939.1; -; Genomic_RNA.
DR   RefSeq; NP_040975.1; NC_001482.1.
DR   SMR; Q66013; -.
DR   GeneID; 1724707; -.
DR   KEGG; vg:1724707; -.
DR   Proteomes; UP000242267; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..78
FT                   /note="Probable Vpr-like protein"
FT                   /id="PRO_0000334542"
FT   MOTIF           35..43
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250"
FT   MOTIF           45..54
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  9649 MW;  F33EFDFA86774DB4 CRC64;
     MEDIIVLFNR VTEKLEKELA IRIFVLAHQL ERDKAIRLLQ GLFWRYRFKK PRVDYCLCWW
     CCKFYYWQLQ STLSITTA