ID   VPRL_FIVSD              Reviewed;          77 AA.
AC   P69469; P19033; P69468;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   23-FEB-2022, entry version 34.
DE   RecName: Full=Probable Vpr-like protein;
DE   AltName: Full=ORF2;
DE   AltName: Full=OrfA;
DE   AltName: Full=Protein Tat;
OS   Feline immunodeficiency virus (strain San Diego) (FIV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11675;
OH   NCBI_TaxID=9681; Felidae (cat family).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate PPR;
RX   PubMed=1697907; DOI=10.1128/jvi.64.10.4605-4613.1990;
RA   Phillips T.R., Talbott R.L., Lamont C., Muir S., Lovelace K.M., Elder J.H.;
RT   "Comparison of two host cell range variants of feline immunodeficiency
RT   virus.";
RL   J. Virol. 64:4605-4613(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1323707; DOI=10.1128/jvi.66.9.5464-5471.1992;
RA   Phillips T.R., Lamont C., Konings D.A.M., Shacklett B.L., Hamson C.A.,
RA   Luciw P.A., Elder J.H.;
RT   "Identification of the Rev transactivation and Rev-responsive elements of
RT   feline immunodeficiency virus.";
RL   J. Virol. 66:5464-5471(1992).
RN   [3]
RP   FUNCTION, NUCLEAR LOCALIZATION SIGNAL, NUCLEAR EXPORT SIGNAL, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=15246256; DOI=10.1016/j.virol.2004.05.007;
RA   Gemeniano M.C., Sawai E.T., Sparger E.E.;
RT   "Feline immunodeficiency virus Orf-A localizes to the nucleus and induces
RT   cell cycle arrest.";
RL   Virology 325:167-174(2004).
CC   -!- FUNCTION: Seems to function as a Vpr-like protein, since it mediates
CC       host cell cycle arrest in G2 phase. Cell cycle arrest creates a
CC       favorable environment for maximizing viral expression and production.
CC       {ECO:0000269|PubMed:15246256}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host nucleus
CC       {ECO:0000269|PubMed:15246256}. Note=Contains both nuclear import and
CC       nuclear export signals.
CC   -!- CAUTION: Was first thought to be the equivalent of lentiviral Tat
CC       protein. {ECO:0000305}.
CC   -!- CAUTION: PubMed:1323707 sequence does not seem to originate from
CC       isolate Petaluma as described, but rather from the strain San Diego.
CC       {ECO:0000305}.
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DR   EMBL; M36968; AAA43078.1; -; Genomic_RNA.
DR   EMBL; S42322; AAB22931.1; -; mRNA.
DR   PIR; A42748; A42748.
DR   SMR; P69469; -.
DR   ELM; P69469; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR035276; FIV_OrfA.
DR   Pfam; PF17495; OrfA; 1.
PE   4: Predicted;
KW   Host nucleus; Virion.
FT   CHAIN           1..77
FT                   /note="Probable Vpr-like protein"
FT                   /id="PRO_0000085512"
FT   MOTIF           34..42
FT                   /note="Nuclear export signal"
FT   MOTIF           44..53
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000269|PubMed:15246256"
SQ   SEQUENCE   77 AA;  9371 MW;  22FF023E0FC9792D CRC64;
     MEVIRIFNKV AERLDKEAAI RIFVLAHQLE RDKLIRLLQG LLWRLRFRKP KSKDCLCWFC
     CRLYYWQLQS TLSIDTA