ID   VPRL_VILV               Reviewed;          94 AA.
AC   P03408;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   29-SEP-2021, entry version 70.
DE   RecName: Full=Probable Vpr-like protein;
DE   AltName: Full=Protein S;
DE   AltName: Full=Protein Tat;
GN   Name=tat;
OS   Maedi visna virus (strain 1514) (MVV) (Visna lentivirus).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11742;
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=2410140; DOI=10.1016/s0092-8674(85)80132-x;
RA   Sonigo P., Alizon M., Staskus K., Klatzmann D., Cole S., Danos O.,
RA   Retzel E., Tiollais P., Haase A., Wain-Hobson S.;
RT   "Nucleotide sequence of the visna lentivirus: relationship to the AIDS
RT   virus.";
RL   Cell 42:369-382(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2824836; DOI=10.1128/jvi.61.12.4046-4054.1987;
RA   Braun M.J., Clements J.E., Gonda M.A.;
RT   "The visna virus genome: evidence for a hypervariable site in the env gene
RT   and sequence homology among lentivirus envelope proteins.";
RL   J. Virol. 61:4046-4054(1987).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2545028; DOI=10.1016/0042-6822(89)90524-2;
RA   Gourdou I., Mazarin V., Querat G., Sauze N., Vigne R.;
RT   "The open reading frame S of visna virus genome is a trans-activating
RT   gene.";
RL   Virology 171:170-178(1989).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2536163; DOI=10.1073/pnas.86.2.414;
RA   Davis J.L., Clements J.E.;
RT   "Characterization of a cDNA clone encoding the visna virus transactivating
RT   protein.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:414-418(1989).
CC   -!- FUNCTION: Seems to function as a Vpr-like protein, since it mediates
CC       host cell cycle arrest in G2 phase. Cell cycle arrest creates a
CC       favorable environment for maximizing viral expression and production
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host nucleus.
CC   -!- CAUTION: Was first thought to be the equivalent of lentiviral Tat
CC       protein, but it does not induce any transactivation of viral LTR
CC       promoter, or if any, at very low rate. The LTR promoter of this virus
CC       has a high basal activity and does apparently not need transactivation
CC       by a Tat-like protein. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA48356.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M10608; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR   EMBL; M51543; AAA48356.1; ALT_INIT; Genomic_RNA.
DR   EMBL; J04359; AAA75436.1; -; mRNA.
DR   EMBL; M23047; AAA48364.1; -; mRNA.
DR   PIR; A32184; TNLJVS.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR004247; Lentiviral_Vpr-like.
DR   Pfam; PF02998; Lentiviral_Tat; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Host nucleus; Virion.
FT   CHAIN           1..94
FT                   /note="Probable Vpr-like protein"
FT                   /id="PRO_0000085490"
FT   CONFLICT        15
FT                   /note="V -> A (in Ref. 3 and 4)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        37
FT                   /note="D -> G (in Ref. 3; AAA75436)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        64
FT                   /note="M -> I (in Ref. 4; AAA48364)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   94 AA;  11280 MW;  27A4AAF4C1296AEA CRC64;
     MEEVPRRQPG GLVEVEGVFQ FYEDWECWDY VSQRVSDERL QRWLAMLTNN QLRRQVIREA
     QIWMWKHKGA AVRRNCGCRL CNPGWGSQVR NVEL