ID   VPRL_VILV2              Reviewed;          94 AA.
AC   P23429;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   29-SEP-2021, entry version 56.
DE   RecName: Full=Probable Vpr-like protein;
DE   AltName: Full=Protein S;
DE   AltName: Full=Protein Tat;
GN   Name=tat;
OS   Maedi visna virus (strain 1514 / clone LV1-1KS2) (MVV) (Visna lentivirus).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11744;
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=1847257; DOI=10.1016/0042-6822(91)90488-w;
RA   Staskus K.A., Retzel E.F., Lewis E.D., Wietgrefe S.W., Silsby J.L., Cyr S.,
RA   Rank J.M., Haase A.T., Fast D., Geiser P.T., Harty J.T., Kong S.H.,
RA   Cook R., Lahti C.J., Neufeld T.P., Porter T.E., Shoop E., Zachow K.R.;
RT   "Isolation of replication-competent molecular clones of visna virus.";
RL   Virology 181:228-240(1991).
CC   -!- FUNCTION: Seems to function as a Vpr-like protein, since it mediates
CC       host cell cycle arrest in G2 phase. Cell cycle arrest creates a
CC       favorable environment for maximizing viral expression and production
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host nucleus.
CC   -!- CAUTION: Was first thought to be the equivalent of lentiviral Tat
CC       protein, but it does not induce any transactivation of viral LTR
CC       promoter, or if any, at very low rate. The LTR promoter of this virus
CC       has a high basal activity and does apparently not need transactivation
CC       by a Tat-like protein. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA17531.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M60610; AAA17531.1; ALT_INIT; Unassigned_DNA.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR004247; Lentiviral_Vpr-like.
DR   Pfam; PF02998; Lentiviral_Tat; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Host nucleus; Virion.
FT   CHAIN           1..94
FT                   /note="Probable Vpr-like protein"
FT                   /id="PRO_0000085492"
SQ   SEQUENCE   94 AA;  11214 MW;  E857A508323E39F8 CRC64;
     MEEVPRRQPG GLVEAEGVFQ VYEDWECWDY VSQRVPDERL QRWLAMLTNN QLRRQVIREA
     QIWMWKHKGA AVRRNCGCRL CNPGWGSQVR NVEL