ID   VPRL_VILVK              Reviewed;          94 AA.
AC   P35958;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   29-SEP-2021, entry version 62.
DE   RecName: Full=Probable Vpr-like protein;
DE   AltName: Full=Protein S;
DE   AltName: Full=Protein Tat;
GN   Name=tat;
OS   Maedi visna virus (strain KV1772) (MVV) (Visna lentivirus).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=36374;
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8382414; DOI=10.1006/viro.1993.1106;
RA   Andresson O.S., Elser J.E., Tobin G.J., Greenwood J.D., Gonda M.A.,
RA   Georgsson G., Andresdottir V., Benediktsdottir E., Carlsdottir H.M.,
RA   Maentylae E.O., Rafnar B., Palsson P.A., Casey J.W., Petursson G.;
RT   "Nucleotide sequence and biological properties of a pathogenic proviral
RT   molecular clone of neurovirulent visna virus.";
RL   Virology 193:89-105(1993).
RN   [2]
RP   FUNCTION.
RX   PubMed=12667801; DOI=10.1016/s0042-6822(02)00076-4;
RA   Villet S., Faure C., Bouzar B.A., Morin T., Verdier G., Chebloune Y.,
RA   Legras C.;
RT   "Lack of trans-activation function for Maedi Visna virus and Caprine
RT   arthritis encephalitis virus Tat proteins.";
RL   Virology 307:317-327(2003).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=12915575; DOI=10.1128/jvi.77.17.9632-9638.2003;
RA   Villet S., Bouzar B.A., Morin T., Verdier G., Legras C., Chebloune Y.;
RT   "Maedi-visna virus and caprine arthritis encephalitis virus genomes encode
RT   a Vpr-like but no Tat protein.";
RL   J. Virol. 77:9632-9638(2003).
CC   -!- FUNCTION: Seems to function as a Vpr-like protein, since it mediates
CC       host cell cycle arrest in G2 phase. Cell cycle arrest creates a
CC       favorable environment for maximizing viral expression and production.
CC       {ECO:0000269|PubMed:12667801, ECO:0000269|PubMed:12915575}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host nucleus
CC       {ECO:0000269|PubMed:12915575}.
CC   -!- CAUTION: Was first thought to be the equivalent of lentiviral Tat
CC       protein, but it does not induce any transactivation of viral LTR
CC       promoter, or if any, at very low rate. The LTR promoter of this virus
CC       has a high basal activity and does apparently not need transactivation
CC       by a Tat-like protein. {ECO:0000305}.
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DR   EMBL; L06906; AAA48361.1; -; Genomic_RNA.
DR   EMBL; S55323; AAB25462.1; -; Genomic_DNA.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR004247; Lentiviral_Vpr-like.
DR   Pfam; PF02998; Lentiviral_Tat; 1.
PE   4: Predicted;
KW   Cell cycle; Host nucleus; Virion.
FT   CHAIN           1..94
FT                   /note="Probable Vpr-like protein"
FT                   /id="PRO_0000085493"
SQ   SEQUENCE   94 AA;  11232 MW;  27A7AAF7C22969EA CRC64;
     MEEVPRRQPG GLVEVEGVFQ FYEDWECWDY VSQRVPGERL QRWLAMLTNN QLRRQVIREA
     QIWMWKHKGA AVRRNCGCRL CNPGWGSQVR NVEL