ID   VPR_HV2BE               Reviewed;          87 AA.
AC   P18100;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   29-SEP-2021, entry version 95.
DE   RecName: Full=Protein Vpr;
DE   AltName: Full=R ORF protein;
DE   AltName: Full=Viral protein R;
GN   Name=vpr;
OS   Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11714;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2353457; DOI=10.1016/0042-6822(90)90484-9;
RA   Kirchhoff F., Jentsch K., Bachmann B., Stuke A., Laloux C., Lueke W.,
RA   Stahl-Henning C., Schneider J., Nieselt K., Eigen M., Hunsmann G.;
RT   "A novel proviral clone of HIV-2: biological and phylogenetic relationship
RT   to other primate immunodeficiency viruses.";
RL   Virology 177:305-311(1990).
CC   -!- FUNCTION: Stimulates gene expression driven by the HIV-2 LTR. Prevents
CC       infected cells from undergoing mitosis and proliferating, by inducing
CC       arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest
CC       creates a favorable environment for maximizing viral expression and
CC       production (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with human UNG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: This isolate is from a German AIDS patient (with
CC       predominantly neurological complications) who was probably infected in
CC       Mali.
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DR   EMBL; M30502; AAB00740.1; -; Genomic_DNA.
DR   RefSeq; NP_056841.1; NC_001722.1.
DR   SMR; P18100; -.
DR   BioGRID; 1205554; 33.
DR   PRIDE; P18100; -.
DR   GeneID; 1724718; -.
DR   KEGG; vg:1724718; -.
DR   Proteomes; UP000002242; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0039592; P:suppression by virus of G2/M transition of host mitotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   InterPro; IPR000012; RetroV_VpR/X.
DR   Pfam; PF00522; VPR; 1.
DR   PRINTS; PR00444; HIVVPRVPX.
PE   3: Inferred from homology;
KW   Activator; AIDS; Cell cycle; Host G2/M cell cycle arrest by virus;
KW   Host nucleus; Host-virus interaction;
KW   Modulation of host cell cycle by virus; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation;
KW   Viral penetration into host nucleus; Virion; Virus entry into host cell.
FT   CHAIN           1..87
FT                   /note="Protein Vpr"
FT                   /id="PRO_0000085456"
FT   MOD_RES         84
FT                   /note="Phosphoserine; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   87 AA;  10071 MW;  CB3424E9A4171DA5 CRC64;
     MTEAPTEFPP EDGTPRRDLG SDWVIETLRE IKEEALRHFD PRLLIALGYY IHNRHGDTLE
     GARELIKTLQ RALFVHFRAG CNRSRIG