ID   VPR_HV2D1               Reviewed;         105 AA.
AC   P17761;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   29-SEP-2021, entry version 92.
DE   RecName: Full=Protein Vpr;
DE   AltName: Full=R ORF protein;
DE   AltName: Full=Viral protein R;
GN   Name=vpr;
OS   Human immunodeficiency virus type 2 subtype A (isolate D194) (HIV-2).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11713;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2467304; DOI=10.1073/pnas.86.7.2383;
RA   Kuehnel H., von Briesen H., Dietrich U., Adamski M., Mix D., Biesert L.,
RA   Kreutz R., Immelmann A., Henco K., Meichsner C., Andreesen R.,
RA   Gelderblom H., Ruebsamen-Waigmann H.;
RT   "Molecular cloning of two west African human immunodeficiency virus type 2
RT   isolates that replicate well in macrophages: a Gambian isolate, from a
RT   patient with neurologic acquired immunodeficiency syndrome, and a highly
RT   divergent Ghanian isolate.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:2383-2387(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2235509; DOI=10.1093/nar/18.20.6142;
RA   Kuehnel H., Kreutz R., Ruebsamen-Waigmann H.;
RT   "Nucleotide sequence of HIV-2D194, an isolate from a Gambian case of
RT   'neuro-AIDS', which showed excellent growth in macrophages.";
RL   Nucleic Acids Res. 18:6142-6142(1990).
CC   -!- FUNCTION: Stimulates gene expression driven by the HIV-2 LTR. Prevents
CC       infected cells from undergoing mitosis and proliferating, by inducing
CC       arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest
CC       creates a favorable environment for maximizing viral expression and
CC       production (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with human UNG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: This isolate is from a Gambian case of 'neuro-AIDS'.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; J04542; AAA76844.1; -; Genomic_DNA.
DR   EMBL; X52223; CAA36468.1; -; Genomic_DNA.
DR   PIR; S12156; S12156.
DR   SMR; P17761; -.
DR   PRIDE; P17761; -.
DR   Proteomes; UP000007422; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0039592; P:suppression by virus of G2/M transition of host mitotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   InterPro; IPR000012; RetroV_VpR/X.
DR   Pfam; PF00522; VPR; 1.
DR   PRINTS; PR00444; HIVVPRVPX.
PE   3: Inferred from homology;
KW   Activator; AIDS; Cell cycle; Host G2/M cell cycle arrest by virus;
KW   Host nucleus; Host-virus interaction;
KW   Modulation of host cell cycle by virus; Phosphoprotein; Transcription;
KW   Transcription regulation; Viral penetration into host nucleus; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..105
FT                   /note="Protein Vpr"
FT                   /id="PRO_0000085455"
FT   REGION          84..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         84
FT                   /note="Phosphoserine; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   105 AA;  11933 MW;  4AEAFAC223FAEC33 CRC64;
     MTEAPTEFPP EDGTPRRELG STWVIETLKE IKEEALKHFD PCLLIALGNY IYNRHGDTLE
     GARELIRVLQ RALFVHIRAG CDRSRKGQTR RRAPCPAAPT PRGMH