ID   VPR_HV2D2               Reviewed;         101 AA.
AC   P15837;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   29-SEP-2021, entry version 84.
DE   RecName: Full=Protein Vpr;
DE   AltName: Full=R ORF protein;
DE   AltName: Full=Viral protein R;
GN   Name=vpr;
OS   Human immunodeficiency virus type 2 subtype B (isolate D205) (HIV-2).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11716;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2594088; DOI=10.1038/342948a0;
RA   Dietrich U., Adamski M., Kreutz R., Seipp A., Kuehnel H.,
RA   Ruebsamen-Waigmann H.;
RT   "A highly divergent HIV-2-related isolate.";
RL   Nature 342:948-950(1989).
CC   -!- FUNCTION: Stimulates gene expression driven by the HIV-2 LTR. Prevents
CC       infected cells from undergoing mitosis and proliferating, by inducing
CC       arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest
CC       creates a favorable environment for maximizing viral expression and
CC       production (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with human UNG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus {ECO:0000250}.
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DR   EMBL; X61240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; S08439; S08439.
DR   SMR; P15837; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0039592; P:suppression by virus of G2/M transition of host mitotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   InterPro; IPR000012; RetroV_VpR/X.
DR   Pfam; PF00522; VPR; 1.
DR   PRINTS; PR00444; HIVVPRVPX.
PE   3: Inferred from homology;
KW   Activator; AIDS; Cell cycle; Host G2/M cell cycle arrest by virus;
KW   Host nucleus; Host-virus interaction;
KW   Modulation of host cell cycle by virus; Phosphoprotein; Transcription;
KW   Transcription regulation; Viral penetration into host nucleus; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..101
FT                   /note="Protein Vpr"
FT                   /id="PRO_0000085458"
FT   MOD_RES         84
FT                   /note="Phosphoserine; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   101 AA;  11220 MW;  1E84528B81BCE0CF CRC64;
     MAEAAPEIPP ENENPQREPW EEWIGEILEE IKQEALKHFD PRLLTALGNF IYSRHGDTLA
     GAGELIKILQ RALFLHFRAG CQHSRIGQSG GGNPLSTIPP P