ID   VPR_HV2RO               Reviewed;         105 AA.
AC   P06938;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   29-SEP-2021, entry version 93.
DE   RecName: Full=Protein Vpr;
DE   AltName: Full=R ORF protein;
DE   AltName: Full=Viral protein R;
GN   Name=vpr;
OS   Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11720;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3031510; DOI=10.1038/326662a0;
RA   Guyader M., Emerman M., Sonigo P., Clavel F., Montagnier L., Alizon M.;
RT   "Genome organization and transactivation of the human immunodeficiency
RT   virus type 2.";
RL   Nature 326:662-669(1987).
CC   -!- FUNCTION: Stimulates gene expression driven by the HIV-2 LTR. Prevents
CC       infected cells from undergoing mitosis and proliferating, by inducing
CC       arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest
CC       creates a favorable environment for maximizing viral expression and
CC       production (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with human UNG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus {ECO:0000250}.
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DR   EMBL; M15390; AAB00767.1; -; Genomic_DNA.
DR   EMBL; X05291; CAA28911.1; -; Genomic_RNA.
DR   PIR; H26262; ASLJR2.
DR   SMR; P06938; -.
DR   Proteomes; UP000007426; Genome.
DR   Proteomes; UP000246871; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0039592; P:suppression by virus of G2/M transition of host mitotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   InterPro; IPR000012; RetroV_VpR/X.
DR   Pfam; PF00522; VPR; 1.
DR   PRINTS; PR00444; HIVVPRVPX.
PE   3: Inferred from homology;
KW   Activator; AIDS; Cell cycle; Host G2/M cell cycle arrest by virus;
KW   Host nucleus; Host-virus interaction;
KW   Modulation of host cell cycle by virus; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation;
KW   Viral penetration into host nucleus; Virion; Virus entry into host cell.
FT   CHAIN           1..105
FT                   /note="Protein Vpr"
FT                   /id="PRO_0000085463"
FT   REGION          84..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..105
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         84
FT                   /note="Phosphoserine; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   105 AA;  11795 MW;  4D2DABC3D4EB2BF9 CRC64;
     MAEAPTELPP VDGTPLREPG DEWIIEILRE IKEEALKHFD PRLLIALGKY IYTRHGDTLE
     GARELIKVLQ RALFTHFRAG CGHSRIGQTR GGNPLSAIPT PRNMQ