ID   VPR_HV2SB               Reviewed;         105 AA.
AC   P12455;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   29-SEP-2021, entry version 89.
DE   RecName: Full=Protein Vpr;
DE   AltName: Full=R ORF protein;
DE   AltName: Full=Viral protein R;
GN   Name=vpr;
OS   Human immunodeficiency virus type 2 subtype A (isolate SBLISY) (HIV-2).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11718;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2648404; DOI=10.1073/pnas.86.7.2433;
RA   Franchini G., Fargnoli K.A., Giombini F., Jagodzinski L.L., de Rossi A.,
RA   Bosch M., Biberfeld G., Fenyo A.M., Albert J., Gallo R.C., Wong-Staal F.;
RT   "Molecular and biological characterization of a replication competent human
RT   immunodeficiency type 2 (HIV-2) proviral clone.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:2433-2437(1989).
CC   -!- FUNCTION: Stimulates gene expression driven by the HIV-2 LTR. Prevents
CC       infected cells from undergoing mitosis and proliferating, by inducing
CC       arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest
CC       creates a favorable environment for maximizing viral expression and
CC       production (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with human UNG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; J04498; AAB00749.1; -; Genomic_DNA.
DR   SMR; P12455; -.
DR   Proteomes; UP000007427; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0039592; P:suppression by virus of G2/M transition of host mitotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   InterPro; IPR000012; RetroV_VpR/X.
DR   Pfam; PF00522; VPR; 1.
DR   PRINTS; PR00444; HIVVPRVPX.
PE   3: Inferred from homology;
KW   Activator; AIDS; Cell cycle; Host G2/M cell cycle arrest by virus;
KW   Host nucleus; Host-virus interaction;
KW   Modulation of host cell cycle by virus; Phosphoprotein; Transcription;
KW   Transcription regulation; Viral penetration into host nucleus; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..105
FT                   /note="Protein Vpr"
FT                   /id="PRO_0000085461"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          83..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         84
FT                   /note="Phosphoserine; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   105 AA;  11975 MW;  3E17584B2D0CC64F CRC64;
     MTEAPAEFPP EDGTPPREPG DEWVIEILRE IKEEALKHFD PRLLTALGYY IYTRHGDTLE
     GARELIRVLQ RALFTHFRAG CGHSRIGQPR GRNPLSAIPT PRNMQ