VPR_HV2ST
ID VPR_HV2ST Reviewed; 104 AA.
AC P20884;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 29-SEP-2021, entry version 98.
DE RecName: Full=Protein Vpr;
DE AltName: Full=R ORF protein;
DE AltName: Full=Viral protein R;
GN Name=vpr;
OS Human immunodeficiency virus type 2 subtype A (isolate ST) (HIV-2).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11721;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2296086; DOI=10.1128/jvi.64.2.890-901.1990;
RA Kumar P., Hui H., Kappes J.C., Haggarty B.S., Hoxie J.A., Arya S.K.,
RA Shaw G.M., Hahn B.H.;
RT "Molecular characterization of an attenuated human immunodeficiency virus
RT type 2 isolate.";
RL J. Virol. 64:890-901(1990).
CC -!- FUNCTION: Stimulates gene expression driven by the HIV-2 LTR. Prevents
CC infected cells from undergoing mitosis and proliferating, by inducing
CC arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest
CC creates a favorable environment for maximizing viral expression and
CC production (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with human UNG. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion. Host nucleus {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M31113; AAB01355.1; -; Genomic_DNA.
DR PIR; E33943; ASLJSY.
DR SMR; P20884; -.
DR Proteomes; UP000007713; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0039592; P:suppression by virus of G2/M transition of host mitotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR InterPro; IPR000012; RetroV_VpR/X.
DR Pfam; PF00522; VPR; 1.
DR PRINTS; PR00444; HIVVPRVPX.
PE 3: Inferred from homology;
KW Activator; AIDS; Cell cycle; Host G2/M cell cycle arrest by virus;
KW Host nucleus; Host-virus interaction;
KW Modulation of host cell cycle by virus; Phosphoprotein; Transcription;
KW Transcription regulation; Viral penetration into host nucleus; Virion;
KW Virus entry into host cell.
FT CHAIN 1..104
FT /note="Protein Vpr"
FT /id="PRO_0000085464"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 83
FT /note="Phosphoserine; by host"
FT /evidence="ECO:0000250"
SQ SEQUENCE 104 AA; 11776 MW; A0D99C1C21A0FEB2 CRC64;
MTEAPTESPP EDRTPPREPG DEWVIETLRE IKEALKHFDP RLLITLGNYI YARHGDTLEG
ARGLIRILQR ALLLHFRAGC GRSRIGQPRG RNPLSAIPTP RGMR