ID   VPR_SIVGB               Reviewed;         104 AA.
AC   P22385;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   29-SEP-2021, entry version 79.
DE   RecName: Full=Protein Vpr;
DE   AltName: Full=R ORF protein;
DE   AltName: Full=Viral protein R;
GN   Name=vpr;
OS   Simian immunodeficiency virus (isolate GB1) (SIV-mnd) (Simian
OS   immunodeficiency virus mandrill).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11732;
OH   NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2797181; DOI=10.1038/341539a0;
RA   Tsujimoto H., Hasegawa A., Maki N., Fukasawa M., Miura T., Speidel S.,
RA   Cooper R.W., Moriyama E.N., Gojobori T., Hayami M.;
RT   "Sequence of a novel simian immunodeficiency virus from a wild-caught
RT   African mandrill.";
RL   Nature 341:539-541(1989).
CC   -!- FUNCTION: Stimulates gene expression driven by the HIV-2 LTR. Prevents
CC       infected cells from undergoing mitosis and proliferating, by inducing
CC       arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest
CC       creates a favorable environment for maximizing viral expression and
CC       production (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with human UNG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: This is an African mandrill isolate.
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DR   EMBL; M27470; AAB49571.1; -; Genomic_RNA.
DR   SMR; P22385; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   InterPro; IPR000012; RetroV_VpR/X.
DR   Pfam; PF00522; VPR; 1.
PE   3: Inferred from homology;
KW   Activator; AIDS; Cell cycle; Host nucleus; Host-virus interaction;
KW   Transcription; Transcription regulation;
KW   Viral penetration into host nucleus; Virion; Virus entry into host cell.
FT   CHAIN           1..104
FT                   /note="Protein Vpr"
FT                   /id="PRO_0000085465"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          85..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   104 AA;  12075 MW;  1D491E033C9336B5 CRC64;
     MGQKRDEQVS EDQGPPREPY NQWLADTMEE IKEEARKHFP LIILNAVSEY CVQNTGSEEE
     ACEKFITLMN RAIWVHLAQG CDGTFRERRP QLPPSGFRPR GDRL