ID   VPR_SIVMK               Reviewed;          97 AA.
AC   P05957;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   29-SEP-2021, entry version 89.
DE   RecName: Full=Protein Vpr;
DE   AltName: Full=R ORF protein;
DE   AltName: Full=Viral protein R;
GN   Name=vpr;
OS   Simian immunodeficiency virus (isolate K6W) (SIV-mac) (Simian
OS   immunodeficiency virus rhesus monkey).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11735;
OH   NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3497350; DOI=10.1038/328539a0;
RA   Franchini G., Gallo R.C., Guo H.-G., Gurgo C., Callatti E., Fargnoli K.,
RA   Hall L., Wong-Staal F., Reitz M.S. Jr.;
RT   "Sequence of simian immunodeficiency virus and its relationship to the
RT   human immunodeficiency viruses.";
RL   Nature 328:539-543(1987).
CC   -!- FUNCTION: Stimulates gene expression driven by the HIV-2 LTR. Prevents
CC       infected cells from undergoing mitosis and proliferating, by inducing
CC       arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest
CC       creates a favorable environment for maximizing viral expression and
CC       production (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with human UNG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: This is a macaque isolate.
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DR   EMBL; M19499; AAB59909.1; ALT_SEQ; Genomic_RNA.
DR   SMR; P05957; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   InterPro; IPR000012; RetroV_VpR/X.
DR   Pfam; PF00522; VPR; 1.
DR   PRINTS; PR00444; HIVVPRVPX.
PE   3: Inferred from homology;
KW   Activator; AIDS; Cell cycle; Host nucleus; Host-virus interaction;
KW   Phosphoprotein; Transcription; Transcription regulation;
KW   Viral penetration into host nucleus; Virion; Virus entry into host cell.
FT   CHAIN           1..97
FT                   /note="Protein Vpr"
FT                   /id="PRO_0000085467"
FT   MOD_RES         80
FT                   /note="Phosphoserine; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   97 AA;  11005 MW;  FD7932FC6FCE5362 CRC64;
     MEERPLENEG PQREPWDEWV VEVLEELKEE ALKHFDPRLL TALGNHIYNR HGDTLEGAGE
     LIRILQRALF MHFRGGCNHS RIGQPGGGNP LSTIPPS