VPR_SIVML
ID VPR_SIVML Reviewed; 122 AA.
AC P11265;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 29-SEP-2021, entry version 86.
DE RecName: Full=Protein Vpr;
DE AltName: Full=R ORF protein;
DE AltName: Full=Viral protein R;
GN Name=vpr;
OS Simian immunodeficiency virus (isolate K78) (SIV-mac) (Simian
OS immunodeficiency virus rhesus monkey).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11736;
OH NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=3646094; DOI=10.1016/0092-8674(87)90283-2;
RA Hirsch V., Riedel N., Mullins J.I.;
RT "The genome organization of STLV-3 is similar to that of the AIDS virus
RT except for a truncated transmembrane protein.";
RL Cell 49:307-319(1987).
CC -!- FUNCTION: Stimulates gene expression driven by the HIV-2 LTR. Prevents
CC infected cells from undergoing mitosis and proliferating, by inducing
CC arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest
CC creates a favorable environment for maximizing viral expression and
CC production (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with human UNG. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion. Host nucleus {ECO:0000250}.
CC -!- MISCELLANEOUS: This is a macaque isolate.
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DR EMBL; M19499; AAB59909.1; ALT_SEQ; Genomic_RNA.
DR PIR; E26737; ASLJRS.
DR SMR; P11265; -.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR InterPro; IPR000012; RetroV_VpR/X.
DR Pfam; PF00522; VPR; 1.
DR PRINTS; PR00444; HIVVPRVPX.
PE 3: Inferred from homology;
KW Activator; AIDS; Cell cycle; Host nucleus; Host-virus interaction;
KW Phosphoprotein; Transcription; Transcription regulation;
KW Viral penetration into host nucleus; Virion; Virus entry into host cell.
FT CHAIN 1..122
FT /note="Protein Vpr"
FT /id="PRO_0000085468"
FT MOD_RES 80
FT /note="Phosphoserine; by host"
FT /evidence="ECO:0000250"
SQ SEQUENCE 122 AA; 14104 MW; 7969E4845B45C117 CRC64;
MEERPLENEG PQREPWDEWV VEVLEELKEE ALKHFDPRLL TALGNHIYNR HGDTLEGAGE
LIRILQRALF MHFRGGCNHS RIGQTWGRKS SLNYTALLRR AITHAIVKSV ATIASFVFLK
RD