ID   VPR_SIVS4               Reviewed;          89 AA.
AC   P12521;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Protein Vpr;
DE   AltName: Full=R ORF protein;
DE   AltName: Full=Viral protein R;
GN   Name=vpr;
OS   Simian immunodeficiency virus (isolate F236/smH4) (SIV-sm) (Simian
OS   immunodeficiency virus sooty mangabey monkey).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11737;
OH   NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2786147; DOI=10.1038/339389a0;
RA   Hirsch V.M., Olmstead R.A., Murphey-Corb M., Purcell R.H., Johnson P.R.;
RT   "An African primate lentivirus (SIVsm) closely related to HIV-2.";
RL   Nature 339:389-392(1989).
CC   -!- FUNCTION: Stimulates gene expression driven by the HIV-2 LTR. Prevents
CC       infected cells from undergoing mitosis and proliferating, by inducing
CC       arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest
CC       creates a favorable environment for maximizing viral expression and
CC       production (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with human UNG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus {ECO:0000250}.
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DR   EMBL; X14307; CAA32486.1; -; Genomic_DNA.
DR   PIR; S07991; S07991.
DR   SMR; P12521; -.
DR   Proteomes; UP000008173; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   InterPro; IPR000012; RetroV_VpR/X.
DR   Pfam; PF00522; VPR; 1.
DR   PRINTS; PR00444; HIVVPRVPX.
PE   3: Inferred from homology;
KW   Activator; AIDS; Cell cycle; Host nucleus; Host-virus interaction;
KW   Phosphoprotein; Transcription; Transcription regulation;
KW   Viral penetration into host nucleus; Virion; Virus entry into host cell.
FT   CHAIN           1..89
FT                   /note="Protein Vpr"
FT                   /id="PRO_0000085469"
FT   MOD_RES         80
FT                   /note="Phosphoserine; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   89 AA;  10280 MW;  604E2FA789722ED4 CRC64;
     MAERPPEDEA PQREPWDEWV VEVLEELKEE ALKHFDPRLL TALGNYIYDR HGDTLEGAGE
     LIRILQRALF IHFRSGCAHS RIGQSRGVL