ID   VPR_SIVSP               Reviewed;         101 AA.
AC   P19509;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   23-FEB-2022, entry version 95.
DE   RecName: Full=Protein Vpr;
DE   AltName: Full=R ORF protein;
DE   AltName: Full=Viral protein R;
GN   Name=vpr;
OS   Simian immunodeficiency virus (isolate PBj14/BCL-3) (SIV-sm) (Simian
OS   immunodeficiency virus sooty mangabey monkey).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11738;
OH   NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1971917; DOI=10.1038/345636a0;
RA   Dewhurst S., Embretson J.E., Anderson D.C., Mullins J.I., Fultz P.N.;
RT   "Sequence analysis and acute pathogenicity of molecularly cloned SIVSMM-
RT   PBj14.";
RL   Nature 345:636-640(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1503826; DOI=10.1089/aid.1992.8.1179;
RA   Dewhurst S., Embretson J.E., Fultz P.N., Mullins J.I.;
RT   "Molecular clones from a non-acutely pathogenic derivative of SIVsmmPBj14:
RT   characterization and comparison to acutely pathogenic clones.";
RL   AIDS Res. Hum. Retroviruses 8:1179-1187(1992).
RN   [3]
RP   FUNCTION.
RX   PubMed=8947037; DOI=10.1002/j.1460-2075.1996.tb01003.x;
RA   Fletcher T.M. III, Brichacek B., Sharova N., Newman M.A., Stivahtis G.,
RA   Sharp P.M., Emerman M., Hahn B.H., Stevenson M.;
RT   "Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein
RT   are encoded by two separate genes in HIV-2/SIV(SM).";
RL   EMBO J. 15:6155-6165(1996).
RN   [4]
RP   INTERACTION WITH HOST UNG.
RX   PubMed=9636373; DOI=10.1006/viro.1998.9159;
RA   Sleigh R., Sharkey M., Newman M.A., Hahn B., Stevenson M.;
RT   "Differential association of uracil DNA glycosylase with SIVSM Vpr and Vpx
RT   proteins.";
RL   Virology 245:338-343(1998).
CC   -!- FUNCTION: Stimulates gene expression driven by the HIV-2 LTR. Prevents
CC       infected cells from undergoing mitosis and proliferating, by inducing
CC       arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest
CC       creates a favorable environment for maximizing viral expression and
CC       production. {ECO:0000269|PubMed:8947037}.
CC   -!- SUBUNIT: Interacts with human UNG. {ECO:0000269|PubMed:9636373}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L03295; AAB59773.1; -; Genomic_RNA.
DR   EMBL; L03298; AAA47780.1; -; Genomic_RNA.
DR   EMBL; M31325; AAA47756.1; -; Genomic_RNA.
DR   SMR; P19509; -.
DR   TCDB; 1.A.42.1.3; the hiv viral protein r (vpr) family.
DR   Proteomes; UP000007221; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   InterPro; IPR000012; RetroV_VpR/X.
DR   Pfam; PF00522; VPR; 1.
DR   PRINTS; PR00444; HIVVPRVPX.
PE   1: Evidence at protein level;
KW   Activator; AIDS; Cell cycle; Host nucleus; Host-virus interaction;
KW   Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Viral penetration into host nucleus; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..101
FT                   /note="Protein Vpr"
FT                   /id="PRO_0000085470"
FT   REGION          80..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         80
FT                   /note="Phosphoserine; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   101 AA;  11429 MW;  0D2156A07042EE98 CRC64;
     MTERPPEDEA PQREPWDEWV VEVLEEIKEE ALNHFDPRLL TALGNYIYDR HGDTLEGAGE
     LIRILQRALF IHFRGGCRHS RIGQSGGGNP LSTIPPSRGV L