ID   VPR_SIVTN               Reviewed;          83 AA.
AC   Q8AIH9;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   23-FEB-2022, entry version 74.
DE   RecName: Full=Protein Vpr;
DE   AltName: Full=R ORF protein;
DE   AltName: Full=Viral protein R;
OS   Simian immunodeficiency virus (isolate TAN1) (SIV-cpz) (Chimpanzee
OS   immunodeficiency virus).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=388910;
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=12525658; DOI=10.1128/jvi.77.3.2233-2242.2003;
RA   Santiago M.L., Bibollet-Ruche F., Bailes E., Kamenya S., Muller M.N.,
RA   Lukasik M., Pusey A.E., Collins D.A., Wrangham R.W., Goodall J., Shaw G.M.,
RA   Sharp P.M., Hahn B.H.;
RT   "Amplification of a complete simian immunodeficiency virus genome from
RT   fecal RNA of a wild chimpanzee.";
RL   J. Virol. 77:2233-2242(2003).
CC   -!- FUNCTION: Stimulates gene expression driven by the HIV-2 LTR. Prevents
CC       infected cells from undergoing mitosis and proliferating, by inducing
CC       arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest
CC       creates a favorable environment for maximizing viral expression and
CC       production (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with human UNG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus {ECO:0000250}.
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DR   EMBL; AF447763; AAO13962.1; -; Genomic_RNA.
DR   SMR; Q8AIH9; -.
DR   Proteomes; UP000007222; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   InterPro; IPR000012; RetroV_VpR/X.
DR   Pfam; PF00522; VPR; 1.
DR   PRINTS; PR00444; HIVVPRVPX.
PE   3: Inferred from homology;
KW   Activator; AIDS; Cell cycle; Host nucleus; Host-virus interaction;
KW   Phosphoprotein; Transcription; Transcription regulation;
KW   Viral penetration into host nucleus; Virion; Virus entry into host cell.
FT   CHAIN           1..83
FT                   /note="Protein Vpr"
FT                   /id="PRO_0000248299"
FT   MOD_RES         79
FT                   /note="Phosphoserine; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   83 AA;  9702 MW;  B64D3FDF3E4AE5C7 CRC64;
     MEQAPNDNGP QREPYTEWLL DILEEIKQEA VKHFPRPILQ GVGNWVFTIY GDSWEGVQEL
     IKILQRALFT HYRHGCIHSR IGS