ID   VPS10_AJECG             Reviewed;        1497 AA.
AC   C0NKP8;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE   AltName: Full=Carboxypeptidase Y receptor;
DE            Short=CPY receptor;
DE   AltName: Full=Sortilin VPS10;
DE   AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE   Flags: Precursor;
GN   Name=VPS10; ORFNames=HCBG_03728;
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432;
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC       required for the intracellular sorting and delivery of soluble vacuolar
CC       proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC       multiple rounds of sorting by cycling between the late Golgi and a
CC       prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC       compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC       prevacuolar compartment. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC       {ECO:0000305}.
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DR   EMBL; GG663366; EEH08439.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0NKP8; -.
DR   SMR; C0NKP8; -.
DR   STRING; 447093.C0NKP8; -.
DR   EnsemblFungi; EEH08439; EEH08439; HCBG_03728.
DR   VEuPathDB; FungiDB:HCBG_03728; -.
DR   HOGENOM; CLU_000700_0_0_1; -.
DR   InParanoid; C0NKP8; -.
DR   OrthoDB; 1046610at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF15902; Sortilin-Vps10; 2.
DR   Pfam; PF15901; Sortilin_C; 2.
DR   SMART; SM00602; VPS10; 2.
PE   3: Inferred from homology;
KW   Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW   Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..1497
FT                   /note="Vacuolar protein sorting/targeting protein 10"
FT                   /id="PRO_0000407494"
FT   TOPO_DOM        22..1361
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1362..1382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1383..1408
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1409..1429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1430..1497
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REPEAT          61..71
FT                   /note="BNR 1"
FT   REPEAT          377..386
FT                   /note="BNR 2"
FT   REPEAT          437..447
FT                   /note="BNR 3"
FT   REPEAT          479..489
FT                   /note="BNR 4"
FT   REPEAT          721..731
FT                   /note="BNR 5"
FT   REPEAT          1105..1115
FT                   /note="BNR 6"
FT   REPEAT          1147..1156
FT                   /note="BNR 7"
FT   REGION          1474..1497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        321
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        970
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1497 AA;  168473 MW;  E0EDF5A6749788A9 CRC64;
     MILRRLLLAG SLLLATAFTS AKKADGPKIS VTKFKDEPVN LFYFDDSDTV MFQDGKNGDV
     YVSRDAGANW DIVDVSGMRG KAWSLLPHPT DRTKAYIMSK GGTHWVTEDQ AKSWREFTVD
     AELSRYEYPL VFHGKDSNRV MLLGHKCNGL DCKERTYYTT DGFKTVHLLM ENGRHCAWAV
     STPTFGEGLD LPKEVNDRIF CVVSGLHSSW AEANRLLYSD RFFKDEQGTE VPLDNGRAVS
     GVIRTASVQK YILAATKSAR TNELALFVTD DASTWHRTEF DGHRVEEDAY TILESTSYSL
     QVDVVSTYSS TIGTLFTSNS NGTYFTRNIE HTNRNMYGFV DFEKISSIQG IILVNTVKNW
     EDVEKSNGVQ KKVISKISFD DGRTFQPLKV GKHDLHLHSV TDATNSGRVF SSPAPGLVMG
     VGNTGGHLKD YLDGDLFVSD DAGINWRKAL DDAHKYEFGD QGSVIVAVFD EGRTDKISYS
     LDHGKNWHKA SLPDGVQIRA KVLTTAPGST TLKFLLLGSA KADIGMEYYI ISIDFAEMEE
     RTCEEKDFEN WPARLNEKNE PDCLMGHKQF YRRRKAQADC FIKKKFEEPA PEFERCKCTE
     EDFECDFNFV RGEDGKSCIP SRSLIAPEGV CKNPDDKFTG SSGFRLIPGN VCIREGGVDL
     DKQTERVCSE TFKNPPAGQI VVEKSFFTAD YYKDYFYLER KESSKGEDET VIMITSEQQI
     FLSRDHGKKW KQILEEEKIT RIEPHRFFDD VAYFLTNNGD GWYTLDRGDT FRKFKAPLPP
     NQDKLPVLSF HPDRRDWLIW TGADECNGNG GNCHSVAYYT TNLGGEWHFL MRYVRRCEFI
     SRDARGSSDK LVFCEQFENE NPSNKHLQLL STEDWFAEKR LHYSNILDFA TMQEFIIVAI
     RGENSQDSLR IGVSIDGKTF ADAELPANVQ IPIQRAYTVL ESRTHAAFLH VTINNIEDHE
     YGSIIKSNSN GTSYVLSLSA VNRNSRGYAD FEKMQGLEGV AMANVVGNVA DVENGAAKKF
     RTMITHNDGA EWTLMRPPDK DSEGRSYACS TKGGKPTDAC ALHLHSYTER ADPRDTYSSP
     SAVGIMIGTG NVGDYLSLKS KADTFITRDA GITWEEVKKG KYQWEFGDSG SIIVLVPEST
     PTKTLLYSLD EGRSWKDFEF SEVEMQIQDI STVPSDTSRN FLLWGKEVGQ GKKPGLATVN
     IDFSGLKERS KQCVLDEKKP EADDYYLWEP KHPLQPNGCL FGHRAKYHRK RPDKDCYNGR
     ELQHLDSIGD ICECTRSDYE CDYNYEPQSD GSCARVAGLE PLDPKLVCTE NPKAVEWYEP
     TGYRRIPLTK CQGGKQLNHI VAHPCPNKEE EFFKKHPRLR GIGLFFVILI PICLAATAGY
     YVYNHWDGKF GRIRLGETGS GGLFDRDSLL VSIPVSMVAG VVAVITALPL LVSSLWRSVS
     GYVRVPGGAS SRRPYSSRDS FAARRSDYVG VVEDEDELLG TDDFDDDEEG DERNGQV