ID   VPS10_AJECH             Reviewed;        1420 AA.
AC   C6HAY7;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE   AltName: Full=Carboxypeptidase Y receptor;
DE            Short=CPY receptor;
DE   AltName: Full=Sortilin VPS10;
DE   AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE   Flags: Precursor;
GN   Name=VPS10; ORFNames=HCDG_03869;
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143;
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC       required for the intracellular sorting and delivery of soluble vacuolar
CC       proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC       multiple rounds of sorting by cycling between the late Golgi and a
CC       prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC       compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC       prevacuolar compartment. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC       {ECO:0000305}.
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DR   EMBL; GG692422; EER42410.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6HAY7; -.
DR   SMR; C6HAY7; -.
DR   STRING; 544712.C6HAY7; -.
DR   PRIDE; C6HAY7; -.
DR   EnsemblFungi; EER42410; EER42410; HCDG_03869.
DR   VEuPathDB; FungiDB:HCDG_03869; -.
DR   HOGENOM; CLU_000700_0_0_1; -.
DR   OMA; ATMSEFI; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF15902; Sortilin-Vps10; 2.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00602; VPS10; 2.
PE   3: Inferred from homology;
KW   Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW   Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..1420
FT                   /note="Vacuolar protein sorting/targeting protein 10"
FT                   /id="PRO_0000407495"
FT   TOPO_DOM        22..1284
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1285..1305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1306..1331
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1332..1352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1353..1420
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REPEAT          61..71
FT                   /note="BNR 1"
FT   REPEAT          377..386
FT                   /note="BNR 2"
FT   REPEAT          644..654
FT                   /note="BNR 3"
FT   REPEAT          1028..1038
FT                   /note="BNR 4"
FT   REPEAT          1070..1079
FT                   /note="BNR 5"
FT   REGION          1397..1420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        271
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        321
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        893
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1420 AA;  159138 MW;  08CCF3482774B994 CRC64;
     MILRRLLLAG SLLLATAFTS AKKADGPKIS VTKFKDEPVN LFYFDDSDTV MFQDGKNGDV
     YVSRDAGANW DIVDVSGMRG KAWSLLPHPT DRTKAYIMSN GGTHWVTEDQ AKSWREFTVD
     ADLSRYEYPL VFHGKDSNRV MLLGHKCNGL DCKEKTYYTT DGFKTAHLLM ENGRHCAWAV
     STPTFGEGLD LPKEVNDRIF CVVSGLHSSW AEANRLLYSD RFFKDEQGTE VPLDNGRAVS
     GVIRTASVQK YILAATKSAR TNELALFVTD NASTWHRTEF DGHRVEEDAY TILESTSYSL
     QVDVVSTYSS TIGTLFTSNS NGTYFTRNIE HTNRNMYGFV DFEKISSIQG IILVNTVKNW
     EDVEKSNGVQ KKVISKISFD DGRTFQPLKV GKHDLHLHSV TDATNSGRVF SSPAPGLVMG
     VGNTGGHLKD YLDGDLFVSD DAGINLEEKL WTMLINMNSV IKASNWHKAS LPDGVQIRAK
     VLTTAPGSTT LKFLLLGSAK ADIGMEYYII SIDFAEMEDA LVRRKTSKIG CQIERENEPD
     ADGHKHPDAP EGVCKNPDDK FTGSSGFRLI PGNVCIREGG VDLDKQTERV CSETFKNPPA
     GQIVVEKSFF TADYYKDYFY LERKESSKGE DETVIMITSE QQIFLSRDHG KKWKQILEEE
     KITRIEPHRF FDDVAYFLTN NGDGWYTLDR GDTFRKFKAP LPPNQDKLPV LSFHPDRRDW
     LIWTGADECN GNGGNCHSVA YYTTNLGGEW HFLMRYVRRC EFISRDARGS SDKLVFCEQF
     ENENPSNKHL QLLSTEDWFA EKRLHYSNIL DFATMQEFII VAIRGENSQD SLRIGVSIDG
     KTFADAELPA NVQIPIQRAY TVLESRTHAA FLHVTINNIE DHEYGSIIKS NSNGTSYVLS
     LSAVNRNSRG YADFEKMQGL EGVAMANVVG NVADVENGAA KKFRTMITHN DGAEWTLMRP
     PDKDSEGRSY ACSTKGGKPT DACALHLHSY TERADPRDTY SSPSAVGIMI GTGNVGDYLS
     LKSKADTFIT RDAGITWEEV KKGKYQWEFG DSGSIIVLVP ESTPTKTLLY SLDEGRSWKD
     FEFSEVEMQI QDISTVPSDT SRNFLLWGKE VGQGKKPGIA TVNIDFSGLK ERSKQCVLDE
     KKPEADDYYL WEPKHPLQPN GCLFGHRAKY HRKRPDKDCY NGRELQHLDS IGDICECTRS
     DYECDYNYEP QSDGSCARVA GLEPLDPKLV CTENPKAVEW YEPTGYRRIP LTKCQGGKQL
     NHIVAHPCPN KEEEFFKKHP RLRGIGLFFV ILIPICLAAT AGYYVYNHWD GKFGRIRLGE
     TGSGGLFDRD SLLVSIPVSM VAGVVAVITA LPLLVSSLWR SVSGYVRVPG GASSRRPYSS
     RDSFAARRSD YVGVVEDEDE LLGTDDFDDD EEGDERNGQV