ID   VPS10_AJEDR             Reviewed;        1500 AA.
AC   C5GVC6;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE   AltName: Full=Carboxypeptidase Y receptor;
DE            Short=CPY receptor;
DE   AltName: Full=Sortilin VPS10;
DE   AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE   Flags: Precursor;
GN   Name=VPS10; ORFNames=BDCG_08556;
OS   Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces
OS   dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=559297;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ER-3 / ATCC MYA-2586;
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA   Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC       required for the intracellular sorting and delivery of soluble vacuolar
CC       proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC       multiple rounds of sorting by cycling between the late Golgi and a
CC       prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC       compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC       prevacuolar compartment. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC       {ECO:0000305}.
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DR   EMBL; EQ999983; EEQ85287.1; -; Genomic_DNA.
DR   AlphaFoldDB; C5GVC6; -.
DR   SMR; C5GVC6; -.
DR   STRING; 559297.C5GVC6; -.
DR   EnsemblFungi; EEQ85287; EEQ85287; BDCG_08556.
DR   VEuPathDB; FungiDB:BDCG_08556; -.
DR   eggNOG; KOG3511; Eukaryota.
DR   HOGENOM; CLU_000700_0_0_1; -.
DR   OMA; ATMSEFI; -.
DR   Proteomes; UP000002039; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF15902; Sortilin-Vps10; 2.
DR   Pfam; PF15901; Sortilin_C; 2.
DR   SMART; SM00602; VPS10; 2.
DR   SUPFAM; SSF50939; SSF50939; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW   Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..1500
FT                   /note="Vacuolar protein sorting/targeting protein 10"
FT                   /id="PRO_0000407497"
FT   TOPO_DOM        23..1364
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1365..1385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1386..1412
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1413..1433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1434..1500
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REPEAT          378..387
FT                   /note="BNR 1"
FT   REPEAT          438..449
FT                   /note="BNR 2"
FT   REPEAT          480..490
FT                   /note="BNR 3"
FT   REPEAT          724..734
FT                   /note="BNR 4"
FT   REPEAT          821..831
FT                   /note="BNR 5"
FT   REPEAT          1108..1118
FT                   /note="BNR 6"
FT   REPEAT          1150..1159
FT                   /note="BNR 7"
FT   REGION          1481..1500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        298
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        322
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        810
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        973
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1500 AA;  168146 MW;  840DAF1501A0A10D CRC64;
     MILRRLLLAA GSLLLASAFT SAKKADGPKI TVTKFKHEPV NLFYFDDSDV VMLQDGNNGD
     VYVSRNAGTK WDIVDVGEMK GQAWSLMPHP MDRTKAYVLG KGGKHWVTND QAMTWREFTV
     DAELSPYQLP LVFHGKDSNR VMLQGIKCSG RDCVERTYYT TDGFQTLHLL MEKGRHCAWA
     VSTPMFGDGL DLPKEVNDRI FCVVSGLHSQ WPEDNRLLYS DRFFKDDSGI EAGLDSGRAV
     SGVIRTASAK RHLLAATKSR RTNELALFVT DDASGWHRAE FDGQRIEEDA YTILESTNYS
     LQVDVVSTDS SAMGTLFTSN SNGTYFTRNI EHTNRNRQGL VDFEKIATIQ GIILVNTVKN
     WEDVEKSSVV EKKIVSRISF DDGRTFQPLK AGKQDLHLHS VTDATNYGRV FSSPAPGLVM
     GVGNTGGHLK DYSDGDLYIS DDAGINWKKA LSDAHKYEFG DQGSVIVAVY DEGRTNKISY
     SFNHGKSWEK ASLPLPDDVK IRAKILTTMP DSTSLKFVLV GSAKADSDVE HYVIAIDFAE
     MEERTCVDPD FEKWPARLNE KQEPDCLMGH KQFYRRRKAD ANCFIKKKFE DPIPNFEPCK
     CTEEDFECDF NFIRSEDGKS CVPARSLLAP EGACKNPDDK YTGSSGFRLI PGDACIKKGG
     LELDKPIERV CSDTMKTPAA GEIAVEKTFF TADNYRDYFY LERTGSSRGD DETVIMITSE
     QEIFISRDHG KRWKRIFEAE TITRIEPHRY FNDVAYFLTN SGEGWYTLDR GENFREFKAP
     LPPNQDKLPA LSFHPDRRDW LIWTGAEECN GSGGQCHSVA YYTTNRGAEW HFLMRYVRRC
     EFIKRDARGS SDKIVFCEQY EDENPSSKHL QLISSEDWFA EKKVHYNNIL DFATMQEFII
     VAIRGEKPQD SLSVGVSIDG KTFADAELPA NVKIPIQRAY TVLESRTHAA FLHVTVNNLE
     DHEYGSLIKS NSNGTSYVLS LSAVNRNSRG YADFEKMQGL EGVAMANVVA NVDDVEKGAA
     KKYRTMITHN DGAEWTLLAP PGKDSEGRAY GCSTKGGKPT KACALHLHSY TERVDPRDTY
     SSPGAVGIMI GTGNVGEYLT PKSSADTFIT RDAGISWEEA KKGKYQWEYG DSGSIIVLVP
     ESTPTKTLLY SLDEGRSWKE YQFSEVEMQI RDISTVPSDT SRNFLLWGNE VGQGKKPGLA
     TVNIDFSGLK ERSKQCVLNE EKPEADDYYL WEPKHPLQPN GCLFGHRAKY HRKRPEKDCY
     NGREIQHLDS IGDICECTRS DYECDYNYEP QTDGTCARVP GLEPLDPKLV CTEDPKAIEW
     YEPTGYRRIP LTKCQGGKQL NHIIAHPCPN KEEEFEKKHP RLRGIGLFFA IVIPIGLAAA
     VGYYVYQHWD GKFGRIRLGE TGSGGFFDRD SPLISIPVTI VAGIVAVATA LPLLVSSLWR
     SLGGYIRVPG SGSSRQPYSS RGAFAARRGD YVGVVDDEDE LLGTDDLEDD EEGEERNGQV