VPS10_ARTGP
ID VPS10_ARTGP Reviewed; 1483 AA.
AC E4UV76;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 1.
DT 25-MAY-2022, entry version 39.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE AltName: Full=Carboxypeptidase Y receptor;
DE Short=CPY receptor;
DE AltName: Full=Sortilin VPS10;
DE AltName: Full=Vacuolar carboxypeptidase sorting receptor VPS10;
DE Flags: Precursor;
GN Name=VPS10; ORFNames=MGYG_05206;
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893;
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Cycles between the Golgi apparatus and the
CC prevacuolar compartment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000305}.
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DR EMBL; DS989825; EFR02203.1; -; Genomic_DNA.
DR RefSeq; XP_003172614.1; XM_003172566.1.
DR AlphaFoldDB; E4UV76; -.
DR SMR; E4UV76; -.
DR STRING; 63402.XP_003172614.1; -.
DR PRIDE; E4UV76; -.
DR EnsemblFungi; EFR02203; EFR02203; MGYG_05206.
DR GeneID; 10027887; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR InParanoid; E4UV76; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 1046610at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Protein transport; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1483
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /id="PRO_0000407500"
FT TOPO_DOM 24..1347
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1348..1368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1369..1399
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1400..1420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1421..1483
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 376..385
FT /note="BNR 1"
FT REPEAT 436..446
FT /note="BNR 2"
FT REPEAT 482..492
FT /note="BNR 3"
FT REPEAT 716..726
FT /note="BNR 4"
FT REPEAT 1098..1108
FT /note="BNR 5"
FT REPEAT 1140..1149
FT /note="BNR 6"
FT CARBOHYD 295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 898
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 963
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1483 AA; 166610 MW; E5EE8D2FE2739578 CRC64;
MIVRSLLLAG SLLLASVVPA AHAKSDGPEI KVKEFDKVPT NPYYFEDTDT VMLSGHMAEL
FISTDAASTW EPLKDKDGLL FPNRYHSQSA VIYGPNRKHW ATFDAAKTWR EFEVPEKLIF
SNEGPRPFTF HGKDPNKVII NAEECLISLC RRVTYYTTDG FKTIKKLLKN DMGCYWAVGT
PVFAEGQKDL PEKLDDRIFC IWAHITPFDR TRRLIYSDTY FSDDKFRAVE IGGREIKGVN
NIALIKKYLV LAASSEGTSE AAIYVSKDAV NWGRAEFYGG PKIRGGSFTV LESTNYSIQV
NAASRRSRRP IGSLFTSDSA GTSFTMNVDG VNEDEKMYTD FEQVSGIQGI FLINLVDNAA
DVKSGQSSEK KIVSRISFDD GRTFKPLKCG DKDLHLHSIT RPSNMGRIFS SPAPGLIMGV
GNTGDKLKEY ENGNLYVSND AGVTWRKALD KSHKYEFGDQ GSLLVAIADD GKDELLTDEI
SYSLNHGKDW KKAKLPHKAA AIWLTTTPDS TSLQFLLIAQ GKGKSYAMSI DFSNVHERKC
EEKDFERWPA RLDEKGEPDC LMGHKQFYRR RKADADCFVK EKFKEPVPET EACKCTKEDF
ECSAGFRRNK DYDCEPDGKL KPADGKCKNP DDKFMGPSGY RMIPGDDCIK KGGVDLEKEV
ERPCKDVTKA PASGQIAVEK TTFETKNLNY RYLERSDTSS GDDETVILRT DDGNLFVTRD
HGKTWQRGKF QEPILQYIPH KYDHDVVYLL TQGKKAYWSI DRAHSFHSFE GKLPVTRTKG
TLPLFFHPDH PDWLIWIGGE NCNGQKCTDL AYYSKNRGDE WDLLLRGVGK CMFAGKKDEL
TADDLIFCSQ HEHEDPRKNL RLVSSVDQFA KTTSIHFDGK PIVGYAKMSE FIVAATKNGT
ELQSFTSVDG KTFAHAAFPP NYHVGAEYAY TVLDSSTHSI FLHVTDHSAQ NNEFGSILKS
NSNGTSYVMS LRDANRNKAD YVDFEKIQVV EGVAMANIVA NADEVRHKGQ DKKFRSMISH
NDASEWALMP PPKKDVEGHS FDCKVKDKGT EECALHIHGY TERRDSRDSM SSGSAVGLII
GVGNVGPYLT TRAESDTFMS RDAGITWHQV RKGRYQWEFG DQGSIVVIVA EEKPTKVLSY
SLDEGETWTD FEFTDKEVKV EDISTVPSDT SRNFLLWARG GSPGELIAYN VDFTGLKERE
KQCVLKKESP EADDYYLWSP KHPQQKSNCL FGHVSVYHRK RPEAKCYNGP KLDRLSSEKK
NCECTRQDYE CDYNYERQSD GSCALVKGLQ PADPMKICKD DPEAVEYFEP TGYRKLPVST
CEGGHQLDHI VARPCPNKKK EFEKKHPGIG GFGIFLAIFF PVTAATAIGY WAFSKWDGKF
GRIRLGESQP ESLFAGNSPL ITIPVAIVAG TVAVITALPL LFSSLWRSFK GYTRLSNPWG
QRQRPYASRD AFAARRGEYV GVVDDEDELL GAEEFEGDDD EEV
